Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4400255..4401036 Replicon chromosome
Accession NZ_AP023294
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4261

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5635_RS21495 Protein ID WP_000626099.1
Coordinates 4400255..4400746 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5635_RS21500 Protein ID WP_001110452.1
Coordinates 4400743..4401036 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5635_RS21455 (4395441) 4395441..4395683 - 243 WP_197603740.1 hypothetical protein -
K5635_RS21460 (4395680) 4395680..4396036 - 357 WP_033567083.1 hypothetical protein -
K5635_RS21465 (4396033) 4396033..4396905 - 873 WP_033567082.1 ParA family protein -
K5635_RS21470 (4397096) 4397096..4397173 - 78 Protein_4218 helix-turn-helix domain-containing protein -
K5635_RS21475 (4397264) 4397264..4397596 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5635_RS21480 (4397668) 4397668..4398045 + 378 WP_000916345.1 EthD family reductase -
K5635_RS21485 (4399078) 4399078..4399152 + 75 Protein_4221 porin family protein -
K5635_RS21490 (4399255) 4399255..4400007 + 753 WP_000842434.1 non-specific acid phosphatase -
K5635_RS21495 (4400255) 4400255..4400746 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5635_RS21500 (4400743) 4400743..4401036 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5635_RS21505 (4401353) 4401353..4401574 + 222 WP_001576552.1 hypothetical protein -
K5635_RS21510 (4401949) 4401949..4402646 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
K5635_RS21515 (4402643) 4402643..4403491 + 849 WP_221061094.1 AraC family transcriptional regulator -
K5635_RS21520 (4403488) 4403488..4403775 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5635_RS21525 (4403798) 4403798..4404013 + 216 WP_001595136.1 hypothetical protein -
K5635_RS21530 (4404021) 4404021..4404290 + 270 WP_010989096.1 hypothetical protein -
K5635_RS21535 (4404584) 4404584..4405489 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37310 WP_000626099.1 NZ_AP023294:c4400746-4400255 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37310 NZ_AP023294:c4400746-4400255 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37310 WP_001110452.1 NZ_AP023294:c4401036-4400743 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37310 NZ_AP023294:c4401036-4400743 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References