Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3477002..3477622 | Replicon | chromosome |
Accession | NZ_AP023294 | ||
Organism | Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4261 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | K5635_RS17125 | Protein ID | WP_001280991.1 |
Coordinates | 3477404..3477622 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | K5635_RS17120 | Protein ID | WP_000344807.1 |
Coordinates | 3477002..3477376 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K5635_RS17110 (3472141) | 3472141..3473334 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
K5635_RS17115 (3473357) | 3473357..3476506 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
K5635_RS17120 (3477002) | 3477002..3477376 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
K5635_RS17125 (3477404) | 3477404..3477622 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
K5635_RS17130 (3477801) | 3477801..3478352 | + | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
K5635_RS17135 (3478469) | 3478469..3478939 | + | 471 | WP_000136181.1 | YlaC family protein | - |
K5635_RS17140 (3478995) | 3478995..3479135 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
K5635_RS17145 (3479141) | 3479141..3479401 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
K5635_RS17150 (3479626) | 3479626..3481176 | + | 1551 | WP_000213139.1 | EAL domain-containing protein | - |
K5635_RS17160 (3481407) | 3481407..3481796 | + | 390 | WP_000961285.1 | MGMT family protein | - |
K5635_RS17165 (3481829) | 3481829..3482398 | - | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T37304 WP_001280991.1 NZ_AP023294:3477404-3477622 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T37304 NZ_AP023294:3477404-3477622 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT37304 WP_000344807.1 NZ_AP023294:3477002-3477376 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT37304 NZ_AP023294:3477002-3477376 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|