Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4401533..4402314 Replicon chromosome
Accession NZ_AP023292
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4233

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5617_RS21500 Protein ID WP_000626099.1
Coordinates 4401533..4402024 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5617_RS21505 Protein ID WP_001110452.1
Coordinates 4402021..4402314 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5617_RS21460 (4396719) 4396719..4396961 - 243 WP_197603740.1 hypothetical protein -
K5617_RS21465 (4396958) 4396958..4397314 - 357 WP_033567083.1 hypothetical protein -
K5617_RS21470 (4397311) 4397311..4398183 - 873 WP_033567082.1 ParA family protein -
K5617_RS21475 (4398374) 4398374..4398451 - 78 Protein_4218 helix-turn-helix domain-containing protein -
K5617_RS21480 (4398542) 4398542..4398874 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5617_RS21485 (4398946) 4398946..4399323 + 378 WP_000916345.1 EthD family reductase -
K5617_RS21490 (4400356) 4400356..4400430 + 75 Protein_4221 porin family protein -
K5617_RS21495 (4400533) 4400533..4401285 + 753 WP_000842434.1 non-specific acid phosphatase -
K5617_RS21500 (4401533) 4401533..4402024 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5617_RS21505 (4402021) 4402021..4402314 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5617_RS21510 (4402631) 4402631..4402852 + 222 WP_001576552.1 hypothetical protein -
K5617_RS21515 (4403117) 4403117..4403992 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5617_RS21520 (4403989) 4403989..4404276 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5617_RS21525 (4404299) 4404299..4404514 + 216 WP_001595136.1 hypothetical protein -
K5617_RS21530 (4404522) 4404522..4404791 + 270 WP_010989096.1 hypothetical protein -
K5617_RS21535 (4405085) 4405085..4405990 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37286 WP_000626099.1 NZ_AP023292:c4402024-4401533 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37286 NZ_AP023292:c4402024-4401533 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37286 WP_001110452.1 NZ_AP023292:c4402314-4402021 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37286 NZ_AP023292:c4402314-4402021 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References