Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4452394..4453175 Replicon chromosome
Accession NZ_AP023291
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain L-4126

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5613_RS21835 Protein ID WP_000626099.1
Coordinates 4452394..4452885 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5613_RS21840 Protein ID WP_001110452.1
Coordinates 4452882..4453175 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5613_RS21795 (4447580) 4447580..4447822 - 243 WP_197603740.1 hypothetical protein -
K5613_RS21800 (4447819) 4447819..4448175 - 357 WP_033567083.1 hypothetical protein -
K5613_RS21805 (4448172) 4448172..4449044 - 873 WP_033567082.1 ParA family protein -
K5613_RS21810 (4449235) 4449235..4449312 - 78 Protein_4282 helix-turn-helix domain-containing protein -
K5613_RS21815 (4449403) 4449403..4449735 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5613_RS21820 (4449807) 4449807..4450184 + 378 WP_000916345.1 EthD family reductase -
K5613_RS21825 (4451217) 4451217..4451291 + 75 Protein_4285 porin family protein -
K5613_RS21830 (4451394) 4451394..4452146 + 753 WP_000842434.1 non-specific acid phosphatase -
K5613_RS21835 (4452394) 4452394..4452885 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5613_RS21840 (4452882) 4452882..4453175 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5613_RS21845 (4453492) 4453492..4453713 + 222 WP_001576552.1 hypothetical protein -
K5613_RS21850 (4453978) 4453978..4454853 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5613_RS21855 (4454850) 4454850..4455137 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5613_RS21860 (4455160) 4455160..4455375 + 216 WP_001595136.1 hypothetical protein -
K5613_RS21865 (4455383) 4455383..4455652 + 270 WP_010989096.1 hypothetical protein -
K5613_RS21870 (4455946) 4455946..4456851 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37262 WP_000626099.1 NZ_AP023291:c4452885-4452394 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37262 NZ_AP023291:c4452885-4452394 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37262 WP_001110452.1 NZ_AP023291:c4453175-4452882 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37262 NZ_AP023291:c4453175-4452882 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References