Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3503421..3504041 Replicon chromosome
Accession NZ_AP023291
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain L-4126

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K5613_RS17220 Protein ID WP_001280991.1
Coordinates 3503823..3504041 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K5613_RS17215 Protein ID WP_000344807.1
Coordinates 3503421..3503795 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5613_RS17205 (3498560) 3498560..3499753 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K5613_RS17210 (3499776) 3499776..3502925 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K5613_RS17215 (3503421) 3503421..3503795 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K5613_RS17220 (3503823) 3503823..3504041 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K5613_RS17225 (3504220) 3504220..3504771 + 552 WP_001278792.1 maltose O-acetyltransferase -
K5613_RS17230 (3504888) 3504888..3505358 + 471 WP_000136181.1 YlaC family protein -
K5613_RS17235 (3505414) 3505414..3505554 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K5613_RS17240 (3505560) 3505560..3505820 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K5613_RS17245 (3506045) 3506045..3507595 + 1551 WP_000213139.1 EAL domain-containing protein -
K5613_RS17255 (3507826) 3507826..3508215 + 390 WP_000961285.1 MGMT family protein -
K5613_RS17260 (3508248) 3508248..3508817 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T37256 WP_001280991.1 NZ_AP023291:3503823-3504041 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T37256 NZ_AP023291:3503823-3504041 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT37256 WP_000344807.1 NZ_AP023291:3503421-3503795 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT37256 NZ_AP023291:3503421-3503795 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References