Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4440833..4441614 | Replicon | chromosome |
| Accession | NZ_AP023289 | ||
| Organism | Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | K5612_RS21720 | Protein ID | WP_000626099.1 |
| Coordinates | 4440833..4441324 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | K5612_RS21725 | Protein ID | WP_001110452.1 |
| Coordinates | 4441321..4441614 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5612_RS21685 (4436828) | 4436828..4437403 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| K5612_RS21695 (4437674) | 4437674..4437751 | - | 78 | Protein_4264 | helix-turn-helix domain-containing protein | - |
| K5612_RS21700 (4437842) | 4437842..4438174 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| K5612_RS21705 (4438246) | 4438246..4438623 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| K5612_RS21710 (4439656) | 4439656..4439730 | + | 75 | Protein_4267 | porin family protein | - |
| K5612_RS21715 (4439833) | 4439833..4440585 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| K5612_RS21720 (4440833) | 4440833..4441324 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| K5612_RS21725 (4441321) | 4441321..4441614 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| K5612_RS21730 (4441931) | 4441931..4442152 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| K5612_RS21735 (4442417) | 4442417..4443292 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| K5612_RS21740 (4443289) | 4443289..4443576 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| K5612_RS21745 (4443599) | 4443599..4443814 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| K5612_RS21750 (4443822) | 4443822..4444091 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| K5612_RS21755 (4444385) | 4444385..4445290 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T37214 WP_000626099.1 NZ_AP023289:c4441324-4440833 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T37214 NZ_AP023289:c4441324-4440833 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT37214 WP_001110452.1 NZ_AP023289:c4441614-4441321 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT37214 NZ_AP023289:c4441614-4441321 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|