Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4440833..4441614 Replicon chromosome
Accession NZ_AP023289
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3837

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5612_RS21720 Protein ID WP_000626099.1
Coordinates 4440833..4441324 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5612_RS21725 Protein ID WP_001110452.1
Coordinates 4441321..4441614 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5612_RS21685 (4436828) 4436828..4437403 + 576 WP_001188509.1 transcriptional regulator -
K5612_RS21695 (4437674) 4437674..4437751 - 78 Protein_4264 helix-turn-helix domain-containing protein -
K5612_RS21700 (4437842) 4437842..4438174 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5612_RS21705 (4438246) 4438246..4438623 + 378 WP_000916345.1 EthD family reductase -
K5612_RS21710 (4439656) 4439656..4439730 + 75 Protein_4267 porin family protein -
K5612_RS21715 (4439833) 4439833..4440585 + 753 WP_000842434.1 non-specific acid phosphatase -
K5612_RS21720 (4440833) 4440833..4441324 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5612_RS21725 (4441321) 4441321..4441614 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5612_RS21730 (4441931) 4441931..4442152 + 222 WP_001576552.1 hypothetical protein -
K5612_RS21735 (4442417) 4442417..4443292 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5612_RS21740 (4443289) 4443289..4443576 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5612_RS21745 (4443599) 4443599..4443814 + 216 WP_001595136.1 hypothetical protein -
K5612_RS21750 (4443822) 4443822..4444091 + 270 WP_010989096.1 hypothetical protein -
K5612_RS21755 (4444385) 4444385..4445290 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37214 WP_000626099.1 NZ_AP023289:c4441324-4440833 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37214 NZ_AP023289:c4441324-4440833 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37214 WP_001110452.1 NZ_AP023289:c4441614-4441321 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37214 NZ_AP023289:c4441614-4441321 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References