Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4477715..4478496 Replicon chromosome
Accession NZ_AP023288
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3835

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5610_RS22075 Protein ID WP_000626099.1
Coordinates 4477715..4478206 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5610_RS22080 Protein ID WP_001110452.1
Coordinates 4478203..4478496 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5610_RS22035 (4472901) 4472901..4473143 - 243 WP_197603740.1 hypothetical protein -
K5610_RS22040 (4473140) 4473140..4473496 - 357 WP_033567083.1 hypothetical protein -
K5610_RS22045 (4473493) 4473493..4474365 - 873 WP_033567082.1 ParA family protein -
K5610_RS22050 (4474556) 4474556..4474633 - 78 Protein_4329 helix-turn-helix domain-containing protein -
K5610_RS22055 (4474724) 4474724..4475056 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5610_RS22060 (4475128) 4475128..4475505 + 378 WP_000916345.1 EthD family reductase -
K5610_RS22065 (4476538) 4476538..4476612 + 75 Protein_4332 porin family protein -
K5610_RS22070 (4476715) 4476715..4477467 + 753 WP_000842434.1 non-specific acid phosphatase -
K5610_RS22075 (4477715) 4477715..4478206 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5610_RS22080 (4478203) 4478203..4478496 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5610_RS22085 (4478813) 4478813..4479034 + 222 WP_001576552.1 hypothetical protein -
K5610_RS22090 (4479299) 4479299..4480174 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5610_RS22095 (4480171) 4480171..4480458 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5610_RS22100 (4480481) 4480481..4480696 + 216 WP_001595136.1 hypothetical protein -
K5610_RS22105 (4480704) 4480704..4480973 + 270 WP_010989096.1 hypothetical protein -
K5610_RS22110 (4481267) 4481267..4482172 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37190 WP_000626099.1 NZ_AP023288:c4478206-4477715 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37190 NZ_AP023288:c4478206-4477715 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37190 WP_001110452.1 NZ_AP023288:c4478496-4478203 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37190 NZ_AP023288:c4478496-4478203 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References