Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4267637..4268153 Replicon chromosome
Accession NZ_AP023288
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-3835

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K5610_RS20970 Protein ID WP_000220578.1
Coordinates 4267637..4267921 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K5610_RS20975 Protein ID WP_000212724.1
Coordinates 4267911..4268153 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5610_RS20955 (4262849) 4262849..4264501 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K5610_RS20960 (4264910) 4264910..4267048 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K5610_RS20965 (4267169) 4267169..4267633 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5610_RS20970 (4267637) 4267637..4267921 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5610_RS20975 (4267911) 4267911..4268153 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5610_RS20980 (4268231) 4268231..4270144 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K5610_RS20985 (4270161) 4270161..4270901 - 741 WP_000779263.1 KDGP aldolase family protein -
K5610_RS20990 (4270898) 4270898..4272016 - 1119 WP_221073678.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K5610_RS20995 (4272000) 4272000..4273133 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T37189 WP_000220578.1 NZ_AP023288:c4267921-4267637 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T37189 NZ_AP023288:c4267921-4267637 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT37189 WP_000212724.1 NZ_AP023288:c4268153-4267911 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT37189 NZ_AP023288:c4268153-4267911 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References