Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2612436..2613422 Replicon chromosome
Accession NZ_AP023287
Organism Mycolicibacterium litorale strain NIIDNTM18

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag NIIDNTM18_RS12640 Protein ID WP_185295971.1
Coordinates 2612844..2613422 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag NIIDNTM18_RS12635 Protein ID WP_185295970.1
Coordinates 2612436..2612828 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIIDNTM18_RS12600 2607956..2608456 + 501 WP_185295964.1 SRPBCC family protein -
NIIDNTM18_RS12605 2608458..2608682 - 225 WP_185295965.1 hypothetical protein -
NIIDNTM18_RS12610 2608752..2609357 + 606 WP_185295966.1 class I SAM-dependent methyltransferase -
NIIDNTM18_RS12615 2609450..2610034 + 585 WP_185296372.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
NIIDNTM18_RS12620 2610044..2610460 - 417 WP_185295967.1 pyridoxamine 5'-phosphate oxidase family protein -
NIIDNTM18_RS12625 2610562..2611575 + 1014 WP_185295968.1 acetamidase/formamidase family protein -
NIIDNTM18_RS12630 2611586..2612347 + 762 WP_185295969.1 SDR family oxidoreductase -
NIIDNTM18_RS12635 2612436..2612828 + 393 WP_185295970.1 hypothetical protein Antitoxin
NIIDNTM18_RS12640 2612844..2613422 + 579 WP_185295971.1 zeta toxin family protein Toxin
NIIDNTM18_RS12645 2613506..2614339 + 834 WP_185295972.1 hypothetical protein -
NIIDNTM18_RS12650 2614431..2615630 - 1200 WP_185295973.1 type III PLP-dependent enzyme -
NIIDNTM18_RS12655 2615599..2616120 - 522 WP_185295974.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-126)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21094.03 Da        Isoelectric Point: 10.0332

>T37168 WP_185295971.1 NZ_AP023287:2612844-2613422 [Mycolicibacterium litorale]
MHRLDLVVGPNGAGKSTFVAFTLGPLLPGSPFVNADDIARQRWPADAERHSYEAARIAAATRTALIRAGQSFIAETVFSH
PSKLDLVAEAHTRDYTVVLHVLLIPEDLAVERVRHRVLAGGHNVAEDKIRQRHRRLWDLVVPAIASCDSATVYDNSHRKG
PRIVAQFAGGNPVGAPNWPDWAPLALRTRWPA

Download         Length: 579 bp

>T37168 NZ_AP023287:2612844-2613422 [Mycolicibacterium litorale]
ATGCACCGACTCGACCTCGTCGTCGGACCGAACGGCGCGGGTAAGTCGACCTTCGTCGCGTTCACGCTGGGTCCCCTCCT
GCCGGGCAGTCCGTTCGTCAACGCCGACGACATCGCGCGGCAGCGCTGGCCCGCCGACGCCGAACGCCACTCGTACGAGG
CCGCACGGATCGCCGCCGCCACCCGCACGGCACTGATCCGGGCGGGCCAGTCCTTCATCGCCGAGACGGTCTTCTCCCAC
CCCTCCAAACTCGACCTCGTCGCCGAGGCGCACACGCGCGACTACACCGTCGTCCTGCACGTGCTGCTGATCCCCGAAGA
CCTCGCGGTCGAACGCGTCAGGCACCGGGTGCTGGCCGGAGGCCACAACGTCGCGGAGGACAAGATCCGGCAGCGCCACC
GTCGGTTGTGGGACCTCGTGGTCCCCGCCATCGCATCATGTGACAGCGCGACGGTGTACGACAACAGCCACCGTAAGGGG
CCGCGCATCGTCGCACAGTTCGCCGGCGGGAACCCGGTCGGCGCTCCGAACTGGCCGGACTGGGCTCCTCTCGCACTGCG
GACGCGATGGCCGGCCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13727.06 Da        Isoelectric Point: 4.6346

>AT37168 WP_185295970.1 NZ_AP023287:2612436-2612828 [Mycolicibacterium litorale]
MAEVADRVTRVAADLIESAAAEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAVLAGEADPSSLNPEEGVVFNAEI
SAAVEEHLARADYGTMLAASGVTTVALDDDGRIVQYRPDGTSVVLDDTSS

Download         Length: 393 bp

>AT37168 NZ_AP023287:2612436-2612828 [Mycolicibacterium litorale]
ATGGCTGAGGTCGCAGACCGGGTGACCCGGGTCGCCGCGGATCTGATCGAGAGCGCGGCCGCCGAGGGCGCGCGGCAGAG
CCGATCCGCCAAGCAGCAGCTTGACCACTGGGCACGCGTCGGGCGGGCGGTCTCGAGCCACCACACCGCCGCCCGTCGCC
GCGTGGAGGCCGTGCTGGCCGGTGAGGCCGACCCGAGCAGTCTGAATCCCGAAGAGGGCGTCGTGTTCAACGCCGAGATC
TCCGCGGCCGTCGAGGAACACCTCGCCCGCGCCGACTACGGAACCATGCTGGCGGCGAGCGGCGTCACCACCGTCGCCCT
CGACGACGACGGACGGATCGTGCAGTACCGACCCGACGGCACGTCCGTCGTCCTCGACGACACGTCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References