Detailed information of TA system TA037166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 920613..921277
• Replicon: chromosome
• Accession: NZ_AP023287
• Organism: Mycolicibacterium litorale strain NIIDNTM18

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NIIDNTM18_RS04410
• Protein ID: WP_185294563.1
• Coordinates: 920849..921277 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NIIDNTM18_RS04405
• Protein ID: WP_185294562.1
• Coordinates: 920613..920852 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIIDNTM18_RS04375	915914..916357	-	444	WP_185294556.1	hypothetical protein	-
NIIDNTM18_RS04380	916592..916993	-	402	WP_185294557.1	hypothetical protein	-
NIIDNTM18_RS04385	917689..919398	-	1710	WP_185294558.1	glycohydrolase toxin TNT-related protein	-
NIIDNTM18_RS04390	919417..919722	-	306	WP_185294559.1	ESX-1 secretion-associated protein	-
NIIDNTM18_RS04395	919776..920084	+	309	WP_185294560.1	type II toxin-antitoxin system CcdA family antitoxin	-
NIIDNTM18_RS04400	920081..920494	+	414	WP_185294561.1	PIN domain-containing protein	-
NIIDNTM18_RS04405	920613..920852	+	240	WP_185294562.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
NIIDNTM18_RS04410	920849..921277	+	429	WP_185294563.1	type II toxin-antitoxin system VapC family toxin	Toxin
NIIDNTM18_RS04415	921681..922625	+	945	WP_185296220.1	mechanosensitive ion channel family protein	-
NIIDNTM18_RS04420	922631..924631	-	2001	WP_185294564.1	oligopeptide transporter, OPT family	-
NIIDNTM18_RS04425	924752..925684	+	933	WP_185294565.1	mechanosensitive ion channel family protein	-
NIIDNTM18_RS04430	925721..926125	-	405	WP_185294566.1	DUF2628 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	908712..927678	18966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-127)

Antitoxin

• SpoVT-AbrB domain (4-42)

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 14967.98 Da
• Isoelectric Point: 9.6908

>T37166 WP_185294563.1 NZ_AP023287:920849-921277 [Mycolicibacterium litorale]
MTAVAVTAVDTSVAVPLLVTSHRQHAMVAKWAKERSLGLGGHALAETYSVLTRLPGDARVSPADAVALIDENFPESFQLG
ARAARSAHREFARRGIAGGATYDGLVALAARERGALLVTRDARARSTYEALGVRTEVLSADT

Nucleotide

• Length: 429 bp

>T37166 NZ_AP023287:920849-921277 [Mycolicibacterium litorale]
TTGACGGCGGTGGCGGTGACGGCGGTCGATACCAGTGTCGCGGTGCCTCTCCTCGTGACCTCGCACCGGCAACACGCCAT
GGTTGCGAAGTGGGCGAAGGAGCGGTCACTTGGCCTCGGTGGGCACGCGCTGGCCGAAACCTACTCAGTGCTGACGCGTC
TTCCCGGCGATGCTCGCGTCAGCCCCGCTGACGCGGTCGCACTGATCGATGAGAACTTTCCCGAGTCGTTCCAGCTCGGC
GCGCGGGCGGCGCGGTCCGCCCATCGTGAGTTCGCTCGGCGGGGGATCGCGGGTGGTGCGACTTATGACGGGCTTGTTGC
CTTGGCGGCTCGTGAGCGCGGTGCCCTGCTGGTCACCCGCGATGCGCGCGCGAGATCAACCTACGAGGCACTCGGGGTGA
GGACGGAAGTGCTGTCAGCCGATACCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8433.67 Da
• Isoelectric Point: 7.0113

>AT37166 WP_185294562.1 NZ_AP023287:920613-920852 [Mycolicibacterium litorale]
MEAVIDSGGRIVLPKQLRDALGLTPGTKVDISAYGGGLHVIPGGRTARLERDENGRLVARADTVVTDEMMFALIDSGRR

Nucleotide

• Length: 240 bp

>AT37166 NZ_AP023287:920613-920852 [Mycolicibacterium litorale]
ATGGAGGCTGTCATCGATTCCGGTGGTCGAATCGTCCTGCCCAAGCAGTTGCGTGATGCGTTGGGTCTGACCCCAGGGAC
CAAGGTGGATATCTCTGCGTACGGCGGTGGACTGCACGTCATTCCCGGCGGGCGAACCGCTCGACTCGAACGGGATGAGA
ATGGGCGCCTGGTCGCGAGAGCGGATACGGTCGTCACCGATGAGATGATGTTTGCGCTCATCGATTCGGGACGGCGTTGA