Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 920081..920852 Replicon chromosome
Accession NZ_AP023287
Organism Mycolicibacterium litorale strain NIIDNTM18

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NIIDNTM18_RS04400 Protein ID WP_185294561.1
Coordinates 920081..920494 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NIIDNTM18_RS04405 Protein ID WP_185294562.1
Coordinates 920613..920852 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIIDNTM18_RS04370 915469..915816 - 348 WP_185296219.1 hypothetical protein -
NIIDNTM18_RS04375 915914..916357 - 444 WP_185294556.1 hypothetical protein -
NIIDNTM18_RS04380 916592..916993 - 402 WP_185294557.1 hypothetical protein -
NIIDNTM18_RS04385 917689..919398 - 1710 WP_185294558.1 glycohydrolase toxin TNT-related protein -
NIIDNTM18_RS04390 919417..919722 - 306 WP_185294559.1 ESX-1 secretion-associated protein -
NIIDNTM18_RS04395 919776..920084 + 309 WP_185294560.1 type II toxin-antitoxin system CcdA family antitoxin -
NIIDNTM18_RS04400 920081..920494 + 414 WP_185294561.1 PIN domain-containing protein Toxin
NIIDNTM18_RS04405 920613..920852 + 240 WP_185294562.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NIIDNTM18_RS04410 920849..921277 + 429 WP_185294563.1 type II toxin-antitoxin system VapC family toxin -
NIIDNTM18_RS04415 921681..922625 + 945 WP_185296220.1 mechanosensitive ion channel family protein -
NIIDNTM18_RS04420 922631..924631 - 2001 WP_185294564.1 oligopeptide transporter, OPT family -
NIIDNTM18_RS04425 924752..925684 + 933 WP_185294565.1 mechanosensitive ion channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 908712..927678 18966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-128)

Antitoxin

SpoVT-AbrB domain

(4-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14746.91 Da        Isoelectric Point: 8.6976

>T37165 WP_185294561.1 NZ_AP023287:920081-920494 [Mycolicibacterium litorale]
MSRPSASPREEVVVDASVMVDLLARAGDRYSAVRARLARTVMHAPAHFDAEVLSALGRLQRGGALTVAQVDAALDELRRA
PVTRHDLAPLVGGAWARRDTLRLADALYVELANTAGLTLLTTDQRLARAWPSADVII

Download         Length: 414 bp

>T37165 NZ_AP023287:920081-920494 [Mycolicibacterium litorale]
ATGAGCAGGCCTTCGGCGTCGCCCCGAGAGGAGGTGGTCGTCGACGCGAGTGTCATGGTTGACCTCCTCGCCCGCGCAGG
TGATCGGTACTCGGCGGTGCGAGCCCGACTGGCGCGGACGGTGATGCATGCACCGGCCCATTTCGATGCCGAGGTGCTTT
CGGCGCTTGGGCGACTGCAGCGCGGCGGTGCGCTCACCGTCGCGCAGGTCGATGCCGCACTCGACGAACTACGGCGGGCG
CCGGTGACGCGGCATGACCTCGCACCCCTGGTGGGCGGAGCGTGGGCGCGCCGCGACACGCTACGACTGGCCGATGCGCT
TTACGTCGAGCTGGCAAATACCGCTGGCCTGACGTTGCTGACGACGGACCAGAGGCTGGCACGTGCTTGGCCTTCCGCTG
ACGTGATCATCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8433.67 Da        Isoelectric Point: 7.0113

>AT37165 WP_185294562.1 NZ_AP023287:920613-920852 [Mycolicibacterium litorale]
MEAVIDSGGRIVLPKQLRDALGLTPGTKVDISAYGGGLHVIPGGRTARLERDENGRLVARADTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT37165 NZ_AP023287:920613-920852 [Mycolicibacterium litorale]
ATGGAGGCTGTCATCGATTCCGGTGGTCGAATCGTCCTGCCCAAGCAGTTGCGTGATGCGTTGGGTCTGACCCCAGGGAC
CAAGGTGGATATCTCTGCGTACGGCGGTGGACTGCACGTCATTCCCGGCGGGCGAACCGCTCGACTCGAACGGGATGAGA
ATGGGCGCCTGGTCGCGAGAGCGGATACGGTCGTCACCGATGAGATGATGTTTGCGCTCATCGATTCGGGACGGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References