Detailed information of TA system TA037136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 8366612..8367246
• Replicon: chromosome
• Accession: NZ_AP023263
• Organism: Mesorhizobium sp. L-8-10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN280_RS38695
• Protein ID: WP_202309429.1
• Coordinates: 8366857..8367246 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN280_RS38690
• Protein ID: WP_202309428.1
• Coordinates: 8366612..8366860 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN280_RS38675	8362139..8364013	+	1875	WP_202315326.1	extracellular solute-binding protein	-
JN280_RS38680	8364308..8365411	+	1104	WP_202309426.1	microcin C ABC transporter permease YejB	-
JN280_RS38685	8365411..8366562	+	1152	WP_202309427.1	ABC transporter permease	-
JN280_RS38690	8366612..8366860	+	249	WP_202309428.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN280_RS38695	8366857..8367246	+	390	WP_202309429.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN280_RS38700	8367243..8368871	+	1629	WP_202309430.1	ABC transporter ATP-binding protein	-
JN280_RS38705	8368946..8369896	+	951	WP_202309431.1	glyoxylate/hydroxypyruvate reductase A	-
JN280_RS38710	8370283..8371713	+	1431	WP_202309432.1	IS1182 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-121)

Antitoxin

• Antitoxin VapB-like (1-81)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14095.03 Da
• Isoelectric Point: 4.7722

>T37136 WP_202309429.1 NZ_AP023263:8366857-8367246 [Mesorhizobium sp. L-8-10]
MIVDASALLAVLLEEPEKDTFRDRMLLAEALSMSPINYLEASVRADDQRHPAKGAELDNLMGEFGIRIATVTAEQAHLAR
EAYQRFGKGNHPAKLNLGDCFAYALSKARGESLLFKGNDFGLTDVEAAL

Nucleotide

• Length: 390 bp

>T37136 NZ_AP023263:8366857-8367246 [Mesorhizobium sp. L-8-10]
ATGATCGTAGACGCTTCGGCTCTGCTGGCGGTGCTTCTTGAGGAGCCAGAGAAAGACACCTTTCGCGACCGCATGCTTCT
GGCCGAGGCGCTCTCCATGTCGCCTATCAATTATCTCGAAGCCTCCGTGCGCGCAGACGACCAGCGGCACCCAGCAAAGG
GAGCGGAGTTGGACAATCTGATGGGAGAGTTCGGCATAAGAATCGCAACCGTGACCGCGGAGCAGGCTCATCTTGCCCGC
GAGGCCTATCAGAGATTCGGCAAGGGCAATCATCCGGCCAAGCTCAATCTGGGCGACTGCTTCGCCTATGCCCTGTCCAA
GGCCCGTGGGGAGTCGTTGCTTTTCAAGGGGAATGATTTTGGCCTGACCGACGTGGAGGCTGCCCTTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9245.40 Da
• Isoelectric Point: 6.7270

>AT37136 WP_202309428.1 NZ_AP023263:8366612-8366860 [Mesorhizobium sp. L-8-10]
MSLNIKNDEVHRLAREVAQHTGESLTSAVLTSLQERLARLKKDSDFELRKARIEEILRRSGPTAPGVTSDHSDLYDEFGL
PK

Nucleotide

• Length: 249 bp

>AT37136 NZ_AP023263:8366612-8366860 [Mesorhizobium sp. L-8-10]
ATGAGCCTGAATATCAAGAACGACGAGGTCCACCGCCTGGCAAGGGAGGTTGCGCAGCACACGGGCGAGTCTCTCACTTC
GGCCGTGCTCACGTCCCTTCAGGAACGGCTGGCACGCCTCAAGAAGGACAGCGATTTCGAGTTGAGAAAGGCTAGGATAG
AGGAGATCCTGCGCAGATCCGGCCCGACGGCACCCGGCGTCACGAGCGACCACTCCGACCTTTACGATGAGTTCGGCCTG
CCGAAATGA