Detailed information of TA system TA037135

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 6760310..6760863
• Replicon: chromosome
• Accession: NZ_AP023263
• Organism: Mesorhizobium sp. L-8-10

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JN280_RS31580
• Protein ID: WP_202308112.1
• Coordinates: 6760310..6760597 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN280_RS31585
• Protein ID: WP_202308113.1
• Coordinates: 6760585..6760863 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN280_RS31560	6755535..6756527	+	993	WP_202308107.1	substrate-binding domain-containing protein	-
JN280_RS31565	6756691..6757641	+	951	WP_202308109.1	sugar-binding protein	-
JN280_RS31570	6757739..6759259	+	1521	WP_202308110.1	sugar ABC transporter ATP-binding protein	-
JN280_RS31575	6759256..6760218	+	963	WP_202308111.1	ABC transporter permease	-
JN280_RS31580	6760310..6760597	-	288	WP_202308112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN280_RS31585	6760585..6760863	-	279	WP_202308113.1	CopG family ribbon-helix-helix protein	Antitoxin
JN280_RS31590	6760935..6761573	-	639	WP_202308114.1	maleylacetoacetate isomerase	-
JN280_RS31595	6761570..6761770	-	201	WP_202308115.1	DUF2783 domain-containing protein	-
JN280_RS31600	6761774..6763369	-	1596	WP_202308116.1	FAD-dependent oxidoreductase	-
JN280_RS31605	6763501..6764466	-	966	WP_202308118.1	MBL fold metallo-hydrolase	-
JN280_RS31610	6764472..6765491	-	1020	WP_202308119.1	fumarylacetoacetate hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10834.37 Da
• Isoelectric Point: 9.8844

>T37135 WP_202308112.1 NZ_AP023263:c6760597-6760310 [Mesorhizobium sp. L-8-10]
MPQVIFAPAAIRDMQRLWDFLRPKSADAVRRAGETIRQGVRALGTHPRMGRLVEGLPEQYREWQIDFGDSGYVARVDDDA
VTILAVRHQKEAGFR

Nucleotide

• Length: 288 bp

>T37135 NZ_AP023263:c6760597-6760310 [Mesorhizobium sp. L-8-10]
ATGCCACAAGTGATATTTGCCCCGGCCGCGATCCGGGACATGCAGCGGCTGTGGGATTTTCTCCGACCCAAGAGCGCCGA
TGCTGTGAGAAGGGCGGGTGAGACGATCAGGCAAGGCGTGCGGGCATTGGGCACGCATCCGCGGATGGGTCGTCTTGTCG
AAGGCCTGCCCGAACAATACCGGGAATGGCAAATCGACTTCGGGGATAGCGGCTATGTTGCCCGTGTCGATGATGATGCC
GTAACGATCTTGGCTGTACGACATCAAAAGGAGGCGGGATTCCGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10694.04 Da
• Isoelectric Point: 6.7230

>AT37135 WP_202308113.1 NZ_AP023263:c6760863-6760585 [Mesorhizobium sp. L-8-10]
MATATSIKLDDELKGRVKQLTESRRRTSHWIMREAIAQYVEREEKREALRQDTLKAWEEFQATGLHATAEEGDKWLASWG
TEGERPVPICHK

Nucleotide

• Length: 279 bp

>AT37135 NZ_AP023263:c6760863-6760585 [Mesorhizobium sp. L-8-10]
ATGGCAACAGCAACATCCATCAAACTCGATGACGAGTTGAAAGGGCGGGTGAAACAGCTCACCGAGTCTCGCCGCCGTAC
CTCGCACTGGATCATGCGCGAAGCCATAGCGCAGTATGTCGAGCGGGAGGAAAAGCGCGAAGCATTGCGGCAGGACACGC
TCAAAGCATGGGAAGAATTTCAGGCGACTGGCCTGCACGCCACGGCAGAGGAAGGCGACAAGTGGCTTGCGAGTTGGGGA
ACTGAAGGCGAACGTCCCGTGCCCATATGCCACAAGTGA