Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3826612..3827279 Replicon chromosome
Accession NZ_AP023263
Organism Mesorhizobium sp. L-8-10

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JN280_RS17760 Protein ID WP_202313961.1
Coordinates 3826860..3827279 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JN280_RS17755 Protein ID WP_202313959.1
Coordinates 3826612..3826860 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN280_RS17725 3822066..3822611 + 546 WP_202313946.1 nuclear transport factor 2 family protein -
JN280_RS17730 3822611..3823132 + 522 WP_202313948.1 flavin reductase family protein -
JN280_RS17735 3823157..3824764 + 1608 WP_202313950.1 SDR family oxidoreductase -
JN280_RS17740 3824761..3825060 + 300 WP_202313952.1 hypothetical protein -
JN280_RS17745 3825103..3826197 + 1095 WP_202313954.1 LLM class flavin-dependent oxidoreductase -
JN280_RS17750 3826259..3826576 - 318 WP_202313956.1 DUF3175 domain-containing protein -
JN280_RS17755 3826612..3826860 + 249 WP_202313959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JN280_RS17760 3826860..3827279 + 420 WP_202313961.1 type II toxin-antitoxin system VapC family toxin Toxin
JN280_RS17765 3827514..3828278 + 765 WP_202313963.1 metallophosphoesterase -
JN280_RS17770 3828384..3829403 - 1020 WP_202314827.1 acyltransferase -
JN280_RS17775 3829430..3830698 - 1269 WP_202313964.1 O-antigen ligase family protein -
JN280_RS17780 3830764..3832053 - 1290 WP_202313965.1 polysaccharide export protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(8-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15217.49 Da        Isoelectric Point: 7.8847

>T37133 WP_202313961.1 NZ_AP023263:3826860-3827279 [Mesorhizobium sp. L-8-10]
MPAIYMLDTNICSFIMRERPASVLARLQNAAESQHQIVISVITYYEMLLGTVGRNASPRHARLVDAFVTRLSTILPWDAA
SAERATGIKQDLAAKGTPIGGNDTMIAGHALAADCVLVTNNTREFSRVQGLRFEDWVKG

Download         Length: 420 bp

>T37133 NZ_AP023263:3826860-3827279 [Mesorhizobium sp. L-8-10]
ATGCCGGCCATCTATATGCTCGACACCAATATTTGCTCATTCATCATGCGCGAACGTCCAGCCTCCGTTCTTGCACGTTT
GCAGAACGCGGCGGAAAGCCAGCACCAGATCGTCATCTCGGTCATCACTTATTACGAAATGCTGCTGGGCACGGTCGGCC
GCAATGCCTCGCCTCGTCATGCGCGGCTGGTGGATGCTTTCGTCACCCGTCTCTCCACCATCCTGCCATGGGATGCGGCG
TCCGCGGAACGCGCCACAGGCATCAAGCAGGATTTGGCGGCCAAGGGAACACCCATAGGCGGCAATGATACGATGATCGC
AGGTCATGCGCTGGCCGCTGATTGTGTGCTGGTGACGAACAACACCCGCGAATTCTCACGTGTGCAGGGGCTGCGGTTTG
AGGATTGGGTGAAGGGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9663.87 Da        Isoelectric Point: 4.5257

>AT37133 WP_202313959.1 NZ_AP023263:3826612-3826860 [Mesorhizobium sp. L-8-10]
MTRTVSIFRNNRNQAIRLPKDFEFQGVTELTIERQGDTILLRPVRPDWLSFMKEPLSDADFLDERPELIEEGRFSLDDDG
KH

Download         Length: 249 bp

>AT37133 NZ_AP023263:3826612-3826860 [Mesorhizobium sp. L-8-10]
ATGACCCGCACCGTGTCCATCTTTCGCAACAACCGCAACCAAGCGATCCGTCTGCCCAAAGATTTTGAGTTCCAGGGGGT
GACCGAATTGACCATTGAGCGGCAGGGCGACACGATACTGCTGCGTCCCGTCCGGCCGGACTGGCTATCGTTCATGAAAG
AACCGCTTAGCGATGCGGATTTCCTCGACGAACGGCCCGAGCTGATCGAAGAGGGACGGTTCTCTCTTGATGATGACGGG
AAGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References