Detailed information of TA system TA037131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3077677..3078317
• Replicon: chromosome
• Accession: NZ_AP023263
• Organism: Mesorhizobium sp. L-8-10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN280_RS14275
• Protein ID: WP_202313019.1
• Coordinates: 3077677..3078063 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN280_RS14280
• Protein ID: WP_202313020.1
• Coordinates: 3078063..3078317 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN280_RS14265	3073906..3074838	-	933	WP_202313017.1	helix-turn-helix domain-containing protein	-
JN280_RS14270	3075069..3077171	+	2103	WP_202313018.1	PQQ-dependent dehydrogenase, methanol/ethanol family	-
JN280_RS14275	3077677..3078063	-	387	WP_202313019.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN280_RS14280	3078063..3078317	-	255	WP_202313020.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN280_RS14285	3078664..3080226	-	1563	WP_202313021.1	sulfatase	-
JN280_RS14290	3080286..3081272	-	987	WP_202313022.1	aliphatic sulfonate ABC transporter substrate-binding protein	-
JN280_RS14295	3081292..3082074	-	783	WP_202314764.1	ABC transporter ATP-binding protein	-
JN280_RS14300	3082092..3082844	-	753	WP_202314765.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 13872.63 Da
• Isoelectric Point: 4.5833

>T37131 WP_202313019.1 NZ_AP023263:c3078063-3077677 [Mesorhizobium sp. L-8-10]
MVIDTSAIVAIALNEPEAPSFEQRIADDPVRLISAATVLEAAMVIEARFGDPGGGEFDLWLHKADVEIVAVKAEHADQAR
RAWRRYGKGRHPAGLNYGDCFSYALAALTGEPLLYKGNDFSQTDIQAA

Nucleotide

• Length: 387 bp

>T37131 NZ_AP023263:c3078063-3077677 [Mesorhizobium sp. L-8-10]
ATGGTCATCGATACCTCGGCCATCGTCGCCATAGCGCTCAATGAGCCGGAAGCACCTTCCTTCGAGCAGCGCATTGCCGA
CGACCCGGTGCGCCTCATCTCTGCCGCAACCGTGCTGGAAGCGGCCATGGTGATCGAGGCCCGCTTCGGCGACCCTGGCG
GCGGCGAGTTCGACCTGTGGCTGCACAAGGCCGATGTCGAGATCGTCGCGGTCAAAGCCGAGCATGCCGACCAGGCCCGC
CGCGCCTGGAGGCGCTACGGCAAGGGCCGCCACCCAGCCGGGCTGAACTACGGCGACTGCTTCTCCTATGCACTGGCCGC
CCTGACCGGCGAGCCCCTACTCTACAAGGGCAACGACTTTTCGCAGACCGATATCCAAGCGGCGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9395.62 Da
• Isoelectric Point: 9.9858

>AT37131 WP_202313020.1 NZ_AP023263:c3078317-3078063 [Mesorhizobium sp. L-8-10]
MALSIKDPETERLARKLATKTGESITIATRRALEERLRRVSSDARKTALLEDLAASRRRWSSLPVLDNRSADEIVGYDEN
GLPS

Nucleotide

• Length: 255 bp

>AT37131 NZ_AP023263:c3078317-3078063 [Mesorhizobium sp. L-8-10]
ATGGCGCTGAGCATCAAAGATCCGGAAACCGAGCGGCTCGCCCGCAAGCTCGCCACGAAAACCGGCGAGAGCATCACCAT
TGCCACACGGCGGGCGCTGGAGGAGCGGCTGCGCCGCGTCAGCTCCGACGCCCGCAAGACCGCACTTCTGGAGGATCTTG
CCGCCAGCCGCCGGCGCTGGAGTTCCCTGCCCGTCCTCGACAATCGCAGCGCCGATGAAATCGTCGGCTACGACGAGAAT
GGGCTGCCGAGCTGA