Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2760582..2761249 Replicon chromosome
Accession NZ_AP023263
Organism Mesorhizobium sp. L-8-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN280_RS12885 Protein ID WP_202312673.1
Coordinates 2760582..2760989 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN280_RS12890 Protein ID WP_202312674.1
Coordinates 2760986..2761249 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN280_RS12865 2756848..2757636 - 789 WP_202314732.1 helix-turn-helix domain-containing protein -
JN280_RS12870 2757726..2758583 + 858 WP_202312669.1 CoA transferase subunit A -
JN280_RS12875 2758580..2759377 + 798 WP_202312671.1 CoA-transferase subunit beta -
JN280_RS12880 2759380..2760585 + 1206 WP_202312672.1 3-oxoadipyl-CoA thiolase -
JN280_RS12885 2760582..2760989 - 408 WP_202312673.1 type II toxin-antitoxin system VapC family toxin Toxin
JN280_RS12890 2760986..2761249 - 264 WP_202312674.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JN280_RS12895 2761316..2762296 - 981 WP_202312675.1 GlxA family transcriptional regulator -
JN280_RS12900 2762441..2763346 + 906 WP_202312676.1 3-keto-5-aminohexanoate cleavage protein -
JN280_RS12905 2763351..2764463 + 1113 WP_202312677.1 carnitine 3-dehydrogenase -
JN280_RS12910 2764468..2765631 + 1164 WP_202312678.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14846.07 Da        Isoelectric Point: 6.8715

>T37129 WP_202312673.1 NZ_AP023263:c2760989-2760582 [Mesorhizobium sp. L-8-10]
MNTRYMLDTNAIGLIVTKRSGPVADRHSKIPPQDICVSAISFGEIQFGLAKRPEATRLAGVTADFFAEVDVLQWSAQEAR
LYGHLRAHMERQAKSLGALDMLIAAHALSVGATLVTSDRAFRLVPDLRIEDWLEG

Download         Length: 408 bp

>T37129 NZ_AP023263:c2760989-2760582 [Mesorhizobium sp. L-8-10]
ATGAATACGCGCTACATGCTCGATACGAACGCTATCGGACTGATCGTGACGAAGCGATCGGGACCTGTCGCCGACCGACA
CAGCAAAATCCCGCCCCAGGATATTTGCGTGTCCGCCATCTCTTTCGGGGAAATCCAGTTTGGGTTGGCAAAGCGCCCGG
AGGCTACCCGTTTGGCGGGGGTAACAGCCGACTTCTTCGCCGAGGTCGACGTGCTGCAATGGTCGGCACAAGAAGCAAGG
CTCTATGGCCACCTCCGCGCCCATATGGAGCGACAGGCGAAAAGCCTAGGCGCACTCGACATGCTCATCGCCGCCCATGC
GCTTTCTGTCGGCGCGACGCTCGTCACGAGCGATCGCGCCTTCCGTCTCGTCCCCGACCTCCGGATCGAGGACTGGCTGG
AGGGTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10064.31 Da        Isoelectric Point: 5.1751

>AT37129 WP_202312674.1 NZ_AP023263:c2761249-2760986 [Mesorhizobium sp. L-8-10]
MTAVAKLFMNGRSQAVRLPQEFRFKGTEVEIWRDPATGHVILAEKPQRTGSWEKFFAARDALRPEDIPEDFLKDRDQGTQ
ERDDPFA

Download         Length: 264 bp

>AT37129 NZ_AP023263:c2761249-2760986 [Mesorhizobium sp. L-8-10]
ATGACAGCCGTCGCAAAGCTCTTCATGAACGGGCGCAGCCAGGCCGTGCGCCTTCCCCAGGAGTTTCGGTTCAAGGGAAC
GGAAGTGGAGATCTGGCGGGACCCGGCAACGGGACACGTGATCCTGGCAGAGAAACCGCAGCGGACAGGGTCGTGGGAGA
AGTTCTTTGCCGCGCGGGACGCGCTCAGGCCGGAGGACATTCCCGAAGATTTCCTGAAGGACCGGGACCAGGGGACTCAG
GAGCGGGACGACCCCTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References