Detailed information of TA system TA037128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1172604..1173242
• Replicon: chromosome
• Accession: NZ_AP023263
• Organism: Mesorhizobium sp. L-8-10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN280_RS05315
• Protein ID: WP_202310515.1
• Coordinates: 1172985..1173242 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN280_RS05310
• Protein ID: WP_202310514.1
• Coordinates: 1172604..1172975 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN280_RS05290	1169060..1169872	+	813	WP_202310511.1	4-hydroxy-tetrahydrodipicolinate reductase	-
JN280_RS05295	1169909..1170526	+	618	WP_202310512.1	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	-
JN280_RS05305	1171077..1172378	+	1302	WP_202310513.1	ISNCY family transposase	-
JN280_RS05310	1172604..1172975	-	372	WP_202310514.1	helix-turn-helix transcriptional regulator	Antitoxin
JN280_RS05315	1172985..1173242	-	258	WP_202310515.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN280_RS05320	1173928..1174284	+	357	WP_202310517.1	septal ring lytic transglycosylase RlpA family protein	-
JN280_RS05325	1174465..1175526	-	1062	WP_202314558.1	D-alanine:D-lactate ligase-like protein	-
JN280_RS05330	1175536..1176405	-	870	WP_202310519.1	SMP-30/gluconolactonase/LRE family protein	-
JN280_RS05335	1176402..1177040	-	639	WP_202310521.1	2-dehydro-3-deoxy-6-phosphogalactonate aldolase	-
JN280_RS05340	1177040..1177807	-	768	WP_202310523.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1167169..1174284	7115

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-80)

Antitoxin

• Cro/C1-type helix-turn-helix domain (66-122)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.97 Da
• Isoelectric Point: 10.7583

>T37128 WP_202310515.1 NZ_AP023263:c1173242-1172985 [Mesorhizobium sp. L-8-10]
MKQITYSRDAIKSLGRMPADTAKRIRDKINQYAANPASLANNVVIMAGAGNEIRRMRVGDWRVIFSETSEVIAIMKVAPR
GGVYE

Nucleotide

• Length: 258 bp

>T37128 NZ_AP023263:c1173242-1172985 [Mesorhizobium sp. L-8-10]
ATGAAGCAGATCACCTATAGCCGCGACGCCATCAAGTCCCTAGGCCGGATGCCGGCCGACACGGCCAAGCGCATCCGAGA
CAAGATCAACCAATATGCGGCAAACCCGGCGAGCCTCGCCAACAACGTTGTCATCATGGCAGGCGCGGGAAATGAAATCC
GCCGGATGAGGGTCGGCGACTGGCGGGTGATCTTTTCGGAAACAAGCGAGGTTATCGCCATCATGAAGGTCGCGCCGCGT
GGCGGCGTCTACGAATAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13619.25 Da
• Isoelectric Point: 4.2042

>AT37128 WP_202310514.1 NZ_AP023263:c1172975-1172604 [Mesorhizobium sp. L-8-10]
MGAQIITTPNGDRMVIIPEEEFIALQEAAEDQEDIRAVETFRGRLARGEEELVPSDVADRIIDGENKVRVWREYRKLSAR
ELAEKAEISAAYLSQIESGARDGSFETIKKVAAALDIGVDDLA

Nucleotide

• Length: 372 bp

>AT37128 NZ_AP023263:c1172975-1172604 [Mesorhizobium sp. L-8-10]
ATGGGAGCACAGATCATTACCACCCCCAATGGTGACCGGATGGTCATCATTCCCGAGGAGGAATTCATTGCCTTGCAGGA
GGCTGCCGAGGACCAGGAGGATATTCGGGCGGTCGAGACCTTCCGCGGGCGCCTGGCGCGTGGCGAGGAAGAGCTTGTTC
CTTCCGATGTTGCCGATCGGATCATCGACGGCGAGAACAAGGTCCGCGTTTGGCGCGAATATCGCAAGCTTTCGGCCCGT
GAACTTGCCGAGAAGGCCGAGATCAGCGCTGCCTATCTATCTCAGATCGAAAGCGGGGCTCGCGACGGCAGCTTTGAGAC
GATCAAAAAAGTCGCCGCTGCGCTCGACATCGGCGTGGATGACTTGGCATGA