Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1172604..1173242 Replicon chromosome
Accession NZ_AP023263
Organism Mesorhizobium sp. L-8-10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JN280_RS05315 Protein ID WP_202310515.1
Coordinates 1172985..1173242 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JN280_RS05310 Protein ID WP_202310514.1
Coordinates 1172604..1172975 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN280_RS05290 1169060..1169872 + 813 WP_202310511.1 4-hydroxy-tetrahydrodipicolinate reductase -
JN280_RS05295 1169909..1170526 + 618 WP_202310512.1 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase -
JN280_RS05305 1171077..1172378 + 1302 WP_202310513.1 ISNCY family transposase -
JN280_RS05310 1172604..1172975 - 372 WP_202310514.1 helix-turn-helix transcriptional regulator Antitoxin
JN280_RS05315 1172985..1173242 - 258 WP_202310515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JN280_RS05320 1173928..1174284 + 357 WP_202310517.1 septal ring lytic transglycosylase RlpA family protein -
JN280_RS05325 1174465..1175526 - 1062 WP_202314558.1 D-alanine:D-lactate ligase-like protein -
JN280_RS05330 1175536..1176405 - 870 WP_202310519.1 SMP-30/gluconolactonase/LRE family protein -
JN280_RS05335 1176402..1177040 - 639 WP_202310521.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
JN280_RS05340 1177040..1177807 - 768 WP_202310523.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1167169..1174284 7115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-80)

Antitoxin

Cro/C1-type helix-turn-helix domain

(66-122)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9439.97 Da        Isoelectric Point: 10.7583

>T37128 WP_202310515.1 NZ_AP023263:c1173242-1172985 [Mesorhizobium sp. L-8-10]
MKQITYSRDAIKSLGRMPADTAKRIRDKINQYAANPASLANNVVIMAGAGNEIRRMRVGDWRVIFSETSEVIAIMKVAPR
GGVYE

Download         Length: 258 bp

>T37128 NZ_AP023263:c1173242-1172985 [Mesorhizobium sp. L-8-10]
ATGAAGCAGATCACCTATAGCCGCGACGCCATCAAGTCCCTAGGCCGGATGCCGGCCGACACGGCCAAGCGCATCCGAGA
CAAGATCAACCAATATGCGGCAAACCCGGCGAGCCTCGCCAACAACGTTGTCATCATGGCAGGCGCGGGAAATGAAATCC
GCCGGATGAGGGTCGGCGACTGGCGGGTGATCTTTTCGGAAACAAGCGAGGTTATCGCCATCATGAAGGTCGCGCCGCGT
GGCGGCGTCTACGAATAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13619.25 Da        Isoelectric Point: 4.2042

>AT37128 WP_202310514.1 NZ_AP023263:c1172975-1172604 [Mesorhizobium sp. L-8-10]
MGAQIITTPNGDRMVIIPEEEFIALQEAAEDQEDIRAVETFRGRLARGEEELVPSDVADRIIDGENKVRVWREYRKLSAR
ELAEKAEISAAYLSQIESGARDGSFETIKKVAAALDIGVDDLA

Download         Length: 372 bp

>AT37128 NZ_AP023263:c1172975-1172604 [Mesorhizobium sp. L-8-10]
ATGGGAGCACAGATCATTACCACCCCCAATGGTGACCGGATGGTCATCATTCCCGAGGAGGAATTCATTGCCTTGCAGGA
GGCTGCCGAGGACCAGGAGGATATTCGGGCGGTCGAGACCTTCCGCGGGCGCCTGGCGCGTGGCGAGGAAGAGCTTGTTC
CTTCCGATGTTGCCGATCGGATCATCGACGGCGAGAACAAGGTCCGCGTTTGGCGCGAATATCGCAAGCTTTCGGCCCGT
GAACTTGCCGAGAAGGCCGAGATCAGCGCTGCCTATCTATCTCAGATCGAAAGCGGGGCTCGCGACGGCAGCTTTGAGAC
GATCAAAAAAGTCGCCGCTGCGCTCGACATCGGCGTGGATGACTTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References