Detailed information of TA system TA037127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1123253..1123827
• Replicon: chromosome
• Accession: NZ_AP023263
• Organism: Mesorhizobium sp. L-8-10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN280_RS05080
• Protein ID: WP_202310441.1
• Coordinates: 1123253..1123636 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN280_RS05085
• Protein ID: WP_202310443.1
• Coordinates: 1123633..1123827 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN280_RS05055	1118884..1119690	-	807	WP_202310433.1	ABC transporter permease	-
JN280_RS05060	1119693..1120418	-	726	WP_202310435.1	ABC transporter permease	-
JN280_RS05065	1120557..1121336	-	780	WP_202310437.1	transporter substrate-binding domain-containing protein	-
JN280_RS05070	1121367..1122179	-	813	WP_202310439.1	ABC transporter ATP-binding protein	-
JN280_RS05075	1122400..1123248	+	849	WP_202314554.1	amidinotransferase	-
JN280_RS05080	1123253..1123636	-	384	WP_202310441.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN280_RS05085	1123633..1123827	-	195	WP_202310443.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN280_RS05090	1124410..1124667	-	258	WP_202310445.1	hypothetical protein	-
JN280_RS05095	1124807..1125541	-	735	Protein_1016	SMP-30/gluconolactonase/LRE family protein	-
JN280_RS05100	1125922..1126338	-	417	WP_202310447.1	carboxymuconolactone decarboxylase family protein	-
JN280_RS05105	1126468..1127163	+	696	WP_202310448.1	GntR family transcriptional regulator	-
JN280_RS05110	1127200..1127955	-	756	WP_202310450.1	SDR family oxidoreductase	-
JN280_RS05115	1127978..1128766	-	789	WP_202310452.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 13736.77 Da
• Isoelectric Point: 6.4858

>T37127 WP_202310441.1 NZ_AP023263:c1123636-1123253 [Mesorhizobium sp. L-8-10]
VKLADTGIWIDHFRHADAELSRTLADDMMLCHPVVIGELALGSLRNRASTLAYLEALREIAVATHAEVMEMVERHQLCSM
GIDYSGAHLLASTLIDGRAELWTRDKRLGAAARKAGVRLASEGGTAG

Nucleotide

• Length: 384 bp

>T37127 NZ_AP023263:c1123636-1123253 [Mesorhizobium sp. L-8-10]
GTGAAGCTTGCCGACACGGGAATCTGGATCGACCACTTCCGTCACGCCGACGCCGAATTGTCGCGGACCCTCGCTGACGA
CATGATGCTGTGCCATCCGGTCGTCATCGGCGAACTTGCTTTGGGAAGCCTGCGCAATCGAGCGTCCACTCTCGCGTATC
TGGAGGCTCTTCGTGAGATCGCCGTGGCCACCCATGCGGAGGTGATGGAAATGGTCGAGCGGCATCAACTCTGCAGCATG
GGCATCGACTATTCCGGCGCGCATCTCCTTGCATCAACTCTGATTGACGGCCGGGCCGAGTTGTGGACCCGCGATAAGCG
TCTGGGCGCTGCGGCCCGCAAGGCCGGCGTGAGGCTCGCAAGCGAAGGCGGCACAGCAGGGTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7032.12 Da
• Isoelectric Point: 10.9368

>AT37127 WP_202310443.1 NZ_AP023263:c1123827-1123633 [Mesorhizobium sp. L-8-10]
MRSTINLDDRLLEEAKALTGTKETAAVVRKALETLVRVEAGRRLIALGGTMTDAEAAPRRRPDR

Nucleotide

• Length: 195 bp

>AT37127 NZ_AP023263:c1123827-1123633 [Mesorhizobium sp. L-8-10]
ATGCGATCGACGATCAACCTGGACGACCGGCTCCTGGAAGAAGCAAAGGCGCTGACCGGGACGAAGGAGACGGCCGCGGT
AGTGCGCAAGGCGCTCGAGACATTGGTACGTGTCGAAGCGGGCAGGCGTCTCATCGCCTTGGGCGGAACAATGACCGATG
CCGAGGCAGCACCGCGCCGGCGGCCTGATCGGTGA