Detailed information of TA system TA037125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 742339..743003
• Replicon: chromosome
• Accession: NZ_AP023263
• Organism: Mesorhizobium sp. L-8-10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN280_RS03325
• Protein ID: WP_202310103.1
• Coordinates: 742339..742746 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN280_RS03330
• Protein ID: WP_202310104.1
• Coordinates: 742743..743003 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN280_RS03305	737966..738889	+	924	WP_202310099.1	ABC transporter permease	-
JN280_RS03310	738879..739688	+	810	WP_202310100.1	ABC transporter permease	-
JN280_RS03315	739727..740761	+	1035	WP_202310101.1	extracellular solute-binding protein	-
JN280_RS03320	740869..742296	+	1428	WP_202310102.1	amidase	-
JN280_RS03325	742339..742746	-	408	WP_202310103.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN280_RS03330	742743..743003	-	261	WP_202310104.1	antitoxin	Antitoxin
JN280_RS03335	743198..744364	-	1167	WP_202310105.1	porin	-
JN280_RS03340	744703..745389	+	687	WP_202310106.1	ribulose-phosphate 3-epimerase	-
JN280_RS03345	745624..746781	-	1158	WP_202310107.1	N-acetylglucosamine-6-phosphate deacetylase	-
JN280_RS03350	746778..747788	-	1011	WP_202314506.1	SIS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (8-45)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14768.97 Da
• Isoelectric Point: 6.4694

>T37125 WP_202310103.1 NZ_AP023263:c742746-742339 [Mesorhizobium sp. L-8-10]
MTNWLLDTNAVIALVTRRSEALMRRVESTEPGALAVSSIVAHELCFGAYRSQKVDFNLETLRLLFADIVILDLDREDARA
AGEIRADLARRGTPIGPHDVLIAGQALARGMPLVTNNTAGFARIAGLRLEDWTRG

Nucleotide

• Length: 408 bp

>T37125 NZ_AP023263:c742746-742339 [Mesorhizobium sp. L-8-10]
ATGACGAACTGGCTTCTCGATACCAACGCGGTCATCGCCCTTGTAACGCGCCGCTCGGAAGCCCTGATGCGCCGGGTCGA
ATCCACCGAACCCGGCGCGCTCGCCGTCTCCTCGATCGTCGCCCATGAACTCTGCTTCGGCGCCTATCGTAGCCAGAAGG
TGGACTTCAATCTCGAAACGCTCCGTCTGCTCTTCGCCGACATCGTGATCCTCGACCTCGACCGCGAGGACGCGCGGGCC
GCCGGCGAGATCAGGGCTGACCTCGCAAGGCGGGGCACGCCGATCGGCCCCCATGACGTCCTGATCGCCGGCCAGGCGCT
TGCGCGCGGCATGCCGCTCGTCACCAACAATACCGCCGGGTTCGCGCGTATAGCCGGATTGCGGCTGGAAGACTGGACCA
GGGGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9767.99 Da
• Isoelectric Point: 7.0162

>AT37125 WP_202310104.1 NZ_AP023263:c743003-742743 [Mesorhizobium sp. L-8-10]
MPHIAKVFQSGNSQAVRLPKDFRFTVDEVEVSREGDAVILRPRPDASRPWASLRAAVERGFSADFMAEGREQPEVQKRPD
LDQAFR

Nucleotide

• Length: 261 bp

>AT37125 NZ_AP023263:c743003-742743 [Mesorhizobium sp. L-8-10]
ATGCCGCATATCGCCAAGGTCTTCCAGTCCGGCAACTCTCAGGCCGTCAGGCTGCCGAAGGATTTCCGCTTCACGGTCGA
TGAGGTCGAGGTCTCGCGCGAGGGCGACGCTGTGATCCTGCGCCCGAGGCCGGACGCCTCCCGCCCTTGGGCCTCCCTGC
GCGCGGCCGTCGAGCGCGGTTTCAGTGCCGACTTCATGGCCGAGGGCCGGGAACAGCCCGAGGTACAGAAGCGTCCCGAT
CTCGACCAGGCGTTTCGATGA