Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 742339..743003 Replicon chromosome
Accession NZ_AP023263
Organism Mesorhizobium sp. L-8-10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN280_RS03325 Protein ID WP_202310103.1
Coordinates 742339..742746 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN280_RS03330 Protein ID WP_202310104.1
Coordinates 742743..743003 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN280_RS03305 737966..738889 + 924 WP_202310099.1 ABC transporter permease -
JN280_RS03310 738879..739688 + 810 WP_202310100.1 ABC transporter permease -
JN280_RS03315 739727..740761 + 1035 WP_202310101.1 extracellular solute-binding protein -
JN280_RS03320 740869..742296 + 1428 WP_202310102.1 amidase -
JN280_RS03325 742339..742746 - 408 WP_202310103.1 type II toxin-antitoxin system VapC family toxin Toxin
JN280_RS03330 742743..743003 - 261 WP_202310104.1 antitoxin Antitoxin
JN280_RS03335 743198..744364 - 1167 WP_202310105.1 porin -
JN280_RS03340 744703..745389 + 687 WP_202310106.1 ribulose-phosphate 3-epimerase -
JN280_RS03345 745624..746781 - 1158 WP_202310107.1 N-acetylglucosamine-6-phosphate deacetylase -
JN280_RS03350 746778..747788 - 1011 WP_202314506.1 SIS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14768.97 Da        Isoelectric Point: 6.4694

>T37125 WP_202310103.1 NZ_AP023263:c742746-742339 [Mesorhizobium sp. L-8-10]
MTNWLLDTNAVIALVTRRSEALMRRVESTEPGALAVSSIVAHELCFGAYRSQKVDFNLETLRLLFADIVILDLDREDARA
AGEIRADLARRGTPIGPHDVLIAGQALARGMPLVTNNTAGFARIAGLRLEDWTRG

Download         Length: 408 bp

>T37125 NZ_AP023263:c742746-742339 [Mesorhizobium sp. L-8-10]
ATGACGAACTGGCTTCTCGATACCAACGCGGTCATCGCCCTTGTAACGCGCCGCTCGGAAGCCCTGATGCGCCGGGTCGA
ATCCACCGAACCCGGCGCGCTCGCCGTCTCCTCGATCGTCGCCCATGAACTCTGCTTCGGCGCCTATCGTAGCCAGAAGG
TGGACTTCAATCTCGAAACGCTCCGTCTGCTCTTCGCCGACATCGTGATCCTCGACCTCGACCGCGAGGACGCGCGGGCC
GCCGGCGAGATCAGGGCTGACCTCGCAAGGCGGGGCACGCCGATCGGCCCCCATGACGTCCTGATCGCCGGCCAGGCGCT
TGCGCGCGGCATGCCGCTCGTCACCAACAATACCGCCGGGTTCGCGCGTATAGCCGGATTGCGGCTGGAAGACTGGACCA
GGGGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9767.99 Da        Isoelectric Point: 7.0162

>AT37125 WP_202310104.1 NZ_AP023263:c743003-742743 [Mesorhizobium sp. L-8-10]
MPHIAKVFQSGNSQAVRLPKDFRFTVDEVEVSREGDAVILRPRPDASRPWASLRAAVERGFSADFMAEGREQPEVQKRPD
LDQAFR

Download         Length: 261 bp

>AT37125 NZ_AP023263:c743003-742743 [Mesorhizobium sp. L-8-10]
ATGCCGCATATCGCCAAGGTCTTCCAGTCCGGCAACTCTCAGGCCGTCAGGCTGCCGAAGGATTTCCGCTTCACGGTCGA
TGAGGTCGAGGTCTCGCGCGAGGGCGACGCTGTGATCCTGCGCCCGAGGCCGGACGCCTCCCGCCCTTGGGCCTCCCTGC
GCGCGGCCGTCGAGCGCGGTTTCAGTGCCGACTTCATGGCCGAGGGCCGGGAACAGCCCGAGGTACAGAAGCGTCCCGAT
CTCGACCAGGCGTTTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References