Detailed information of TA system TA037122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 8361915..8362549
• Replicon: chromosome
• Accession: NZ_AP023262
• Organism: Mesorhizobium sp. L-8-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN302_RS38415
• Protein ID: WP_202309429.1
• Coordinates: 8362160..8362549 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN302_RS38410
• Protein ID: WP_202309428.1
• Coordinates: 8361915..8362163 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN302_RS38395	8357442..8359316	+	1875	WP_202334587.1	extracellular solute-binding protein	-
JN302_RS38400	8359611..8360714	+	1104	WP_202309426.1	microcin C ABC transporter permease YejB	-
JN302_RS38405	8360714..8361865	+	1152	WP_202309427.1	ABC transporter permease	-
JN302_RS38410	8361915..8362163	+	249	WP_202309428.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JN302_RS38415	8362160..8362549	+	390	WP_202309429.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN302_RS38420	8362546..8364174	+	1629	WP_202331121.1	ABC transporter ATP-binding protein	-
JN302_RS38425	8364249..8365199	+	951	WP_202331122.1	glyoxylate/hydroxypyruvate reductase A	-
JN302_RS38430	8365598..8366266	-	669	WP_202309433.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-121)

Antitoxin

• Antitoxin VapB-like (1-81)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14095.03 Da
• Isoelectric Point: 4.7722

>T37122 WP_202309429.1 NZ_AP023262:8362160-8362549 [Mesorhizobium sp. L-8-3]
MIVDASALLAVLLEEPEKDTFRDRMLLAEALSMSPINYLEASVRADDQRHPAKGAELDNLMGEFGIRIATVTAEQAHLAR
EAYQRFGKGNHPAKLNLGDCFAYALSKARGESLLFKGNDFGLTDVEAAL

Nucleotide

• Length: 390 bp

>T37122 NZ_AP023262:8362160-8362549 [Mesorhizobium sp. L-8-3]
ATGATCGTAGACGCTTCGGCTCTGCTGGCGGTGCTTCTTGAGGAGCCAGAGAAAGACACCTTTCGCGACCGCATGCTTCT
GGCCGAGGCGCTCTCCATGTCGCCTATCAATTATCTCGAAGCCTCCGTGCGCGCAGACGACCAGCGGCACCCAGCAAAGG
GAGCGGAGTTGGACAATCTGATGGGAGAGTTCGGCATAAGAATCGCAACCGTGACCGCGGAGCAGGCTCATCTTGCCCGC
GAGGCCTATCAGAGATTCGGCAAGGGCAATCATCCGGCCAAGCTCAATCTGGGCGACTGCTTCGCCTATGCCCTGTCCAA
GGCCCGTGGGGAGTCGTTGCTTTTCAAGGGGAATGATTTTGGCCTGACCGACGTGGAGGCTGCCCTTTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9245.40 Da
• Isoelectric Point: 6.7270

>AT37122 WP_202309428.1 NZ_AP023262:8361915-8362163 [Mesorhizobium sp. L-8-3]
MSLNIKNDEVHRLAREVAQHTGESLTSAVLTSLQERLARLKKDSDFELRKARIEEILRRSGPTAPGVTSDHSDLYDEFGL
PK

Nucleotide

• Length: 249 bp

>AT37122 NZ_AP023262:8361915-8362163 [Mesorhizobium sp. L-8-3]
ATGAGCCTGAATATCAAGAACGACGAGGTCCACCGCCTGGCAAGGGAGGTTGCGCAGCACACGGGCGAGTCTCTCACTTC
GGCCGTGCTCACGTCCCTTCAGGAACGGCTGGCACGCCTCAAGAAGGACAGCGATTTCGAGTTGAGAAAGGCTAGGATAG
AGGAGATCCTGCGCAGATCCGGCCCGACGGCACCCGGCGTCACGAGCGACCACTCCGACCTTTACGATGAGTTCGGCCTG
CCGAAATGA