Detailed information of TA system TA037121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 6610564..6611117
• Replicon: chromosome
• Accession: NZ_AP023262
• Organism: Mesorhizobium sp. L-8-3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: JN302_RS30660
• Protein ID: WP_202308112.1
• Coordinates: 6610564..6610851 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN302_RS30665
• Protein ID: WP_202308113.1
• Coordinates: 6610839..6611117 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN302_RS30640	6605791..6606783	+	993	WP_202330187.1	substrate-binding domain-containing protein	-
JN302_RS30645	6606945..6607895	+	951	WP_202308109.1	sugar-binding protein	-
JN302_RS30650	6607993..6609513	+	1521	WP_202330188.1	sugar ABC transporter ATP-binding protein	-
JN302_RS30655	6609510..6610472	+	963	WP_202330189.1	ABC transporter permease	-
JN302_RS30660	6610564..6610851	-	288	WP_202308112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN302_RS30665	6610839..6611117	-	279	WP_202308113.1	CopG family ribbon-helix-helix protein	Antitoxin
JN302_RS30670	6611189..6611827	-	639	WP_202330190.1	maleylacetoacetate isomerase	-
JN302_RS30675	6611824..6612024	-	201	WP_202308115.1	DUF2783 domain-containing protein	-
JN302_RS30680	6612028..6613623	-	1596	WP_202330191.1	FAD-dependent oxidoreductase	-
JN302_RS30685	6613755..6614720	-	966	WP_202330192.1	MBL fold metallo-hydrolase	-
JN302_RS30690	6614726..6615745	-	1020	WP_202330193.1	fumarylacetoacetate hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10834.37 Da
• Isoelectric Point: 9.8844

>T37121 WP_202308112.1 NZ_AP023262:c6610851-6610564 [Mesorhizobium sp. L-8-3]
MPQVIFAPAAIRDMQRLWDFLRPKSADAVRRAGETIRQGVRALGTHPRMGRLVEGLPEQYREWQIDFGDSGYVARVDDDA
VTILAVRHQKEAGFR

Nucleotide

• Length: 288 bp

>T37121 NZ_AP023262:c6610851-6610564 [Mesorhizobium sp. L-8-3]
ATGCCACAAGTGATATTTGCCCCGGCCGCGATCCGGGACATGCAGCGGCTGTGGGATTTTCTCCGACCCAAGAGCGCCGA
TGCTGTGAGAAGGGCGGGTGAGACGATCAGGCAAGGCGTGCGGGCATTGGGCACGCATCCGCGGATGGGTCGTCTTGTCG
AAGGCCTGCCCGAACAATACCGGGAATGGCAAATCGACTTCGGGGATAGCGGCTATGTTGCCCGTGTCGATGATGATGCC
GTAACGATCTTGGCTGTACGACATCAAAAGGAGGCGGGATTCCGATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10694.04 Da
• Isoelectric Point: 6.7230

>AT37121 WP_202308113.1 NZ_AP023262:c6611117-6610839 [Mesorhizobium sp. L-8-3]
MATATSIKLDDELKGRVKQLTESRRRTSHWIMREAIAQYVEREEKREALRQDTLKAWEEFQATGLHATAEEGDKWLASWG
TEGERPVPICHK

Nucleotide

• Length: 279 bp

>AT37121 NZ_AP023262:c6611117-6610839 [Mesorhizobium sp. L-8-3]
ATGGCAACAGCAACATCCATCAAACTCGATGACGAGTTGAAAGGGCGGGTGAAACAGCTCACCGAGTCTCGCCGCCGTAC
CTCGCACTGGATCATGCGCGAAGCCATAGCGCAGTATGTCGAGCGGGAGGAAAAGCGCGAAGCATTGCGGCAGGACACGC
TCAAAGCATGGGAAGAATTTCAGGCGACTGGCCTGCACGCCACGGCAGAGGAAGGCGACAAGTGGCTTGCGAGTTGGGGA
ACTGAAGGCGAACGTCCCGTGCCCATATGCCACAAGTGA