Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 5857854..5858515 Replicon chromosome
Accession NZ_AP023262
Organism Mesorhizobium sp. L-8-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN302_RS27220 Protein ID WP_202329791.1
Coordinates 5858078..5858515 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN302_RS27215 Protein ID WP_202329790.1
Coordinates 5857854..5858081 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN302_RS27195 5853047..5854681 - 1635 WP_202329788.1 tryptophan 7-halogenase -
JN302_RS27200 5855167..5856783 - 1617 WP_202307204.1 MFS transporter -
JN302_RS27205 5857043..5857507 - 465 WP_202307206.1 transcriptional regulator NrdR -
JN302_RS27210 5857528..5857833 + 306 WP_202329789.1 hypothetical protein -
JN302_RS27215 5857854..5858081 + 228 WP_202329790.1 ribbon-helix-helix domain-containing protein Antitoxin
JN302_RS27220 5858078..5858515 + 438 WP_202329791.1 PIN domain-containing protein Toxin
JN302_RS27225 5858638..5858979 - 342 Protein_5396 transcriptional repressor NrdR -
JN302_RS27230 5859114..5860430 - 1317 WP_202329792.1 serine hydroxymethyltransferase -
JN302_RS27235 5860640..5861893 - 1254 WP_202329793.1 murein L,D-transpeptidase -
JN302_RS27240 5862211..5862726 - 516 WP_202329794.1 winged helix DNA-binding protein -
JN302_RS27245 5863037..5863465 - 429 WP_202307221.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15662.88 Da        Isoelectric Point: 7.4208

>T37120 WP_202329791.1 NZ_AP023262:5858078-5858515 [Mesorhizobium sp. L-8-3]
VIYLLDVNVLIALIDPGHIAHDDAHRWFELAGQASWATCPITENGVMRIVGSPKYPNSPGSPALVADIVKRLRALPGHQF
WPDDASLVSSRDIDTDRIRTSAQVTDTYLLSLAKSNGGQLATFDRKLSPDAVKGGKAALHLIPSK

Download         Length: 438 bp

>T37120 NZ_AP023262:5858078-5858515 [Mesorhizobium sp. L-8-3]
GTGATCTATCTGCTTGACGTCAATGTGCTAATCGCACTGATCGATCCGGGTCACATTGCTCACGACGACGCTCATCGGTG
GTTCGAATTGGCAGGGCAAGCGTCTTGGGCAACTTGTCCCATAACCGAGAATGGGGTCATGCGGATTGTCGGCAGTCCAA
AGTACCCAAACTCTCCAGGCTCTCCCGCCCTCGTCGCAGACATCGTCAAGAGGTTGCGGGCGCTTCCCGGGCACCAGTTT
TGGCCCGATGATGCAAGCCTTGTCAGTTCACGTGACATTGATACCGACAGAATCCGGACCTCTGCGCAGGTGACCGATAC
CTATCTGCTATCGCTCGCCAAGTCCAACGGGGGCCAACTCGCAACCTTTGACCGTAAATTGTCACCTGATGCGGTAAAAG
GTGGAAAGGCTGCGCTCCATCTGATTCCGAGCAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8332.55 Da        Isoelectric Point: 6.3147

>AT37120 WP_202329790.1 NZ_AP023262:5857854-5858081 [Mesorhizobium sp. L-8-3]
MRTTLAIDDDVLVAAKAMARQQDRSLGEVISELARRSLRRPRIGGERNGIPLLSPRPDSPPVTLELVNELRDELS

Download         Length: 228 bp

>AT37120 NZ_AP023262:5857854-5858081 [Mesorhizobium sp. L-8-3]
ATGCGAACGACACTGGCGATCGATGATGATGTTCTGGTCGCGGCCAAGGCGATGGCCCGGCAGCAGGACCGAAGCCTCGG
AGAGGTGATCTCCGAGTTGGCGCGGCGTTCCTTGCGCAGGCCGAGGATCGGCGGCGAACGCAATGGCATTCCGCTGTTGT
CGCCCCGCCCCGACAGCCCCCCCGTTACGCTAGAGCTCGTCAATGAATTGCGCGACGAACTTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References