Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3893867..3894534 Replicon chromosome
Accession NZ_AP023262
Organism Mesorhizobium sp. L-8-3

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag JN302_RS18195 Protein ID WP_202313961.1
Coordinates 3894115..3894534 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag JN302_RS18190 Protein ID WP_202333976.1
Coordinates 3893867..3894115 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN302_RS18160 3889318..3889863 + 546 WP_202313946.1 nuclear transport factor 2 family protein -
JN302_RS18165 3889863..3890384 + 522 WP_202313948.1 flavin reductase family protein -
JN302_RS18170 3890409..3892016 + 1608 WP_202333974.1 SDR family oxidoreductase -
JN302_RS18175 3892013..3892312 + 300 WP_202313952.1 hypothetical protein -
JN302_RS18180 3892355..3893449 + 1095 WP_202313954.1 LLM class flavin-dependent oxidoreductase -
JN302_RS18185 3893511..3893831 - 321 WP_202333975.1 DUF3175 domain-containing protein -
JN302_RS18190 3893867..3894115 + 249 WP_202333976.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JN302_RS18195 3894115..3894534 + 420 WP_202313961.1 type II toxin-antitoxin system VapC family toxin Toxin
JN302_RS18200 3894769..3895533 + 765 WP_202313963.1 metallophosphoesterase -
JN302_RS18205 3895639..3896658 - 1020 WP_202334327.1 acyltransferase -
JN302_RS18210 3896685..3897953 - 1269 WP_202313964.1 O-antigen ligase family protein -
JN302_RS18215 3898019..3899308 - 1290 WP_202313965.1 polysaccharide export protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(8-55)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15217.49 Da        Isoelectric Point: 7.8847

>T37119 WP_202313961.1 NZ_AP023262:3894115-3894534 [Mesorhizobium sp. L-8-3]
MPAIYMLDTNICSFIMRERPASVLARLQNAAESQHQIVISVITYYEMLLGTVGRNASPRHARLVDAFVTRLSTILPWDAA
SAERATGIKQDLAAKGTPIGGNDTMIAGHALAADCVLVTNNTREFSRVQGLRFEDWVKG

Download         Length: 420 bp

>T37119 NZ_AP023262:3894115-3894534 [Mesorhizobium sp. L-8-3]
ATGCCGGCCATCTATATGCTCGACACCAATATTTGCTCATTCATCATGCGCGAACGTCCAGCCTCCGTTCTTGCACGTTT
GCAGAACGCGGCGGAAAGCCAGCACCAGATCGTCATCTCGGTCATCACTTATTACGAAATGCTGCTGGGCACGGTCGGCC
GCAATGCCTCGCCTCGTCATGCGCGGCTGGTGGATGCTTTCGTCACCCGTCTCTCCACCATCCTGCCATGGGATGCGGCG
TCCGCGGAACGCGCCACAGGCATCAAGCAGGATTTGGCGGCCAAGGGAACACCCATAGGCGGCAATGATACGATGATCGC
GGGTCATGCGCTGGCCGCTGATTGTGTGCTGGTGACGAACAACACCCGCGAATTCTCACGTGTGCAGGGGCTGCGGTTTG
AGGATTGGGTGAAGGGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9629.85 Da        Isoelectric Point: 4.5257

>AT37119 WP_202333976.1 NZ_AP023262:3893867-3894115 [Mesorhizobium sp. L-8-3]
MTRTVSIFRNNRNQAIRLPKDFEFQGVTELTIERQGDTILLRPVRPDWLSLMKEPLSDADFLDERPELIEEGRFSLDDDG
KH

Download         Length: 249 bp

>AT37119 NZ_AP023262:3893867-3894115 [Mesorhizobium sp. L-8-3]
ATGACCCGCACCGTGTCCATCTTTCGCAACAACCGCAACCAAGCGATCCGTCTGCCCAAAGATTTTGAGTTCCAGGGGGT
GACCGAATTGACCATTGAGCGGCAGGGCGACACGATCCTGCTGCGTCCCGTCCGGCCGGACTGGCTATCGCTCATGAAAG
AACCGCTTAGCGATGCGGATTTCCTCGACGAACGGCCCGAGTTGATCGAAGAGGGACGGTTCTCTCTTGATGATGACGGG
AAGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References