Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3582349..3583127 Replicon chromosome
Accession NZ_AP023262
Organism Mesorhizobium sp. L-8-3

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JN302_RS16725 Protein ID WP_202333764.1
Coordinates 3582636..3583127 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag JN302_RS16720 Protein ID WP_202333763.1
Coordinates 3582349..3582639 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN302_RS16705 3577637..3578929 + 1293 WP_202333760.1 hypothetical protein -
JN302_RS16710 3579008..3580183 + 1176 WP_202333761.1 DUF2333 family protein -
JN302_RS16715 3580416..3582095 + 1680 WP_202333762.1 formate--tetrahydrofolate ligase -
JN302_RS16720 3582349..3582639 + 291 WP_202333763.1 DUF1778 domain-containing protein Antitoxin
JN302_RS16725 3582636..3583127 + 492 WP_202333764.1 GNAT family N-acetyltransferase Toxin
JN302_RS16730 3583256..3583789 - 534 WP_202314803.1 nucleoside-diphosphate kinase -
JN302_RS16735 3583931..3584344 - 414 WP_202333765.1 nucleoside diphosphate kinase regulator -
JN302_RS16740 3584627..3585400 - 774 WP_202313538.1 amino acid ABC transporter ATP-binding protein -
JN302_RS16745 3585397..3586077 - 681 WP_202333766.1 ABC transporter permease subunit -
JN302_RS16750 3586252..3587025 - 774 WP_202333768.1 amino acid ABC transporter substrate-binding protein -
JN302_RS16755 3587257..3587970 - 714 WP_202333769.1 DUF1868 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(40-143)

Antitoxin

Vibrio phage ICP1, Orf50

(5-90)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17927.66 Da        Isoelectric Point: 7.4748

>T37118 WP_202333764.1 NZ_AP023262:3582636-3583127 [Mesorhizobium sp. L-8-3]
VTEFRIEKLHRRHAVDAFDCGEELLNRFLVRFALPNQQANASQTYVGLADDAVIGFHTLVVGEVGYGDAPDRLTMGLARH
PVPVMLLARLGVSVGWQGRGIGAGLLRDAVLRTLQAADIVGIRAIAVHAKNEQARSFYQRFDFVESPTDPLHLFALIKDL
KGL

Download         Length: 492 bp

>T37118 NZ_AP023262:3582636-3583127 [Mesorhizobium sp. L-8-3]
GTGACGGAGTTCCGCATTGAAAAACTCCATCGTCGCCATGCCGTCGATGCGTTTGATTGCGGCGAGGAACTGCTGAACCG
GTTCCTTGTCCGTTTCGCGCTGCCCAATCAGCAGGCCAACGCTTCGCAAACCTATGTGGGGTTGGCCGATGACGCCGTTA
TAGGCTTTCATACCCTGGTCGTTGGCGAGGTCGGCTACGGTGACGCGCCGGATCGTCTGACCATGGGCCTTGCGCGCCAT
CCGGTGCCCGTGATGCTTTTGGCCCGCCTTGGCGTCAGCGTCGGTTGGCAGGGCAGGGGTATCGGCGCGGGTCTGCTGCG
CGACGCCGTTCTACGCACGTTGCAAGCCGCGGACATCGTCGGCATCAGGGCTATCGCGGTTCATGCCAAGAACGAACAGG
CGCGCTCCTTCTATCAGCGGTTCGATTTCGTGGAATCGCCCACTGATCCGTTGCATCTGTTCGCGCTCATCAAGGATTTG
AAAGGCTTGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10740.26 Da        Isoelectric Point: 7.0168

>AT37118 WP_202333763.1 NZ_AP023262:3582349-3582639 [Mesorhizobium sp. L-8-3]
MAPRTTRTEKLDIRLTPEAKRVLAAAAQAERRSLTDFVLKSALGRAEEALADRRVFLLNPEQWETFIAALDAPPRDMPHL
RNLLNEPSIFSGDSPS

Download         Length: 291 bp

>AT37118 NZ_AP023262:3582349-3582639 [Mesorhizobium sp. L-8-3]
ATGGCTCCACGCACGACCCGCACCGAAAAACTCGATATCCGCCTGACCCCCGAGGCGAAACGTGTGCTGGCCGCCGCCGC
GCAGGCCGAGCGCCGTTCACTGACTGACTTCGTGCTCAAAAGCGCTCTCGGCCGTGCCGAGGAGGCGCTGGCCGACCGCC
GTGTGTTCTTGCTCAACCCCGAACAGTGGGAAACTTTCATCGCAGCCCTCGATGCGCCGCCGCGCGACATGCCGCACCTG
CGCAATCTGCTGAACGAGCCGAGCATCTTCTCCGGCGACAGCCCTTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References