Detailed information of TA system TA037115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2783307..2783826
• Replicon: chromosome
• Accession: NZ_AP023262
• Organism: Mesorhizobium sp. L-8-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN302_RS13105
• Protein ID: WP_202333163.1
• Coordinates: 2783545..2783826 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN302_RS13100
• Protein ID: WP_202333162.1
• Coordinates: 2783307..2783555 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN302_RS13085	2779267..2780097	-	831	WP_202333161.1	ABC transporter permease	-
JN302_RS13090	2780108..2781067	-	960	WP_202312692.1	ABC transporter permease	-
JN302_RS13095	2781082..2782671	-	1590	WP_202312694.1	twin-arginine translocation signal domain-containing protein	-
JN302_RS13100	2783307..2783555	+	249	WP_202333162.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JN302_RS13105	2783545..2783826	+	282	WP_202333163.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN302_RS13110	2783840..2784433	-	594	WP_202333164.1	nucleoside deaminase	-
JN302_RS13115	2784438..2784938	-	501	WP_202333165.1	ureidoglycolate lyase	-
JN302_RS13120	2785022..2785855	-	834	WP_202333166.1	(S)-ureidoglycine aminohydrolase	-
JN302_RS13125	2785867..2787300	-	1434	WP_202333167.1	allantoinase PuuE	-
JN302_RS13130	2787485..2787850	+	366	WP_202333168.1	hydroxyisourate hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11187.16 Da
• Isoelectric Point: 10.4973

>T37115 WP_202333163.1 NZ_AP023262:2783545-2783826 [Mesorhizobium sp. L-8-3]
MKYDIEFLEPALKEWKRLDANTRDQFRKKLKERCENPRIPAAKLFGAKDRYKIKLRSIGYRLVYEVVDDRLVVLVIAIGK
RERSEIYETAKKR

Nucleotide

• Length: 282 bp

>T37115 NZ_AP023262:2783545-2783826 [Mesorhizobium sp. L-8-3]
ATGAAATATGACATCGAGTTCCTCGAACCCGCCCTGAAGGAATGGAAACGGCTTGATGCCAATACGCGTGACCAGTTCCG
AAAGAAGCTGAAGGAACGGTGCGAGAATCCTCGGATTCCGGCAGCGAAGCTGTTCGGAGCGAAGGACCGCTACAAGATCA
AGCTGCGGAGCATCGGCTACCGGCTGGTCTATGAAGTCGTCGATGACAGGCTGGTGGTTCTCGTCATCGCCATCGGAAAA
CGTGAGCGATCGGAGATATACGAGACGGCGAAGAAGCGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8902.18 Da
• Isoelectric Point: 4.2942

>AT37115 WP_202333162.1 NZ_AP023262:2783307-2783555 [Mesorhizobium sp. L-8-3]
MPHTILAEVTASVSELKKNPMGTVAAGDGFPVAILNHNEPAFYCVPAKAFEALMDRLEDLELNAIADARKDEPRVPVNLD
EI

Nucleotide

• Length: 249 bp

>AT37115 NZ_AP023262:2783307-2783555 [Mesorhizobium sp. L-8-3]
ATGCCCCATACGATCCTGGCCGAGGTGACGGCGAGCGTTTCGGAGCTGAAGAAGAATCCCATGGGTACGGTCGCAGCAGG
GGACGGCTTCCCGGTGGCAATCCTCAATCACAACGAACCGGCCTTTTACTGTGTTCCTGCAAAGGCTTTCGAAGCGCTGA
TGGACCGGCTCGAGGACCTGGAGCTCAATGCCATCGCAGATGCCCGCAAGGATGAACCGCGGGTCCCGGTCAATCTCGAT
GAAATATGA