Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2765681..2766348 Replicon chromosome
Accession NZ_AP023262
Organism Mesorhizobium sp. L-8-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN302_RS13025 Protein ID WP_202312673.1
Coordinates 2765681..2766088 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN302_RS13030 Protein ID WP_202312674.1
Coordinates 2766085..2766348 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN302_RS13005 2761947..2762735 - 789 WP_202314732.1 helix-turn-helix domain-containing protein -
JN302_RS13010 2762825..2763682 + 858 WP_202333151.1 CoA transferase subunit A -
JN302_RS13015 2763679..2764476 + 798 WP_202312671.1 CoA-transferase subunit beta -
JN302_RS13020 2764479..2765684 + 1206 WP_202333152.1 3-oxoadipyl-CoA thiolase -
JN302_RS13025 2765681..2766088 - 408 WP_202312673.1 type II toxin-antitoxin system VapC family toxin Toxin
JN302_RS13030 2766085..2766348 - 264 WP_202312674.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JN302_RS13035 2766415..2767395 - 981 WP_202333153.1 GlxA family transcriptional regulator -
JN302_RS13040 2767540..2768445 + 906 WP_202333154.1 3-keto-5-aminohexanoate cleavage protein -
JN302_RS13045 2768450..2769562 + 1113 WP_202312677.1 carnitine 3-dehydrogenase -
JN302_RS13050 2769567..2770730 + 1164 WP_202312678.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14846.07 Da        Isoelectric Point: 6.8715

>T37114 WP_202312673.1 NZ_AP023262:c2766088-2765681 [Mesorhizobium sp. L-8-3]
MNTRYMLDTNAIGLIVTKRSGPVADRHSKIPPQDICVSAISFGEIQFGLAKRPEATRLAGVTADFFAEVDVLQWSAQEAR
LYGHLRAHMERQAKSLGALDMLIAAHALSVGATLVTSDRAFRLVPDLRIEDWLEG

Download         Length: 408 bp

>T37114 NZ_AP023262:c2766088-2765681 [Mesorhizobium sp. L-8-3]
ATGAATACGCGCTACATGCTCGATACGAACGCTATCGGACTGATCGTGACGAAGCGATCGGGACCTGTCGCCGACCGACA
CAGCAAAATCCCGCCCCAGGATATTTGCGTGTCCGCCATCTCTTTCGGGGAAATCCAGTTTGGGTTGGCAAAGCGCCCGG
AGGCTACCCGTTTGGCGGGGGTAACAGCCGACTTCTTCGCCGAGGTCGACGTGCTGCAATGGTCGGCACAAGAAGCAAGG
CTCTATGGCCACCTCCGCGCCCATATGGAGCGACAGGCGAAAAGCCTAGGCGCACTCGACATGCTCATCGCCGCCCATGC
GCTTTCTGTCGGCGCGACGCTCGTCACGAGCGATCGCGCCTTCCGTCTCGTCCCCGACCTCCGGATCGAGGACTGGCTGG
AGGGTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10064.31 Da        Isoelectric Point: 5.1751

>AT37114 WP_202312674.1 NZ_AP023262:c2766348-2766085 [Mesorhizobium sp. L-8-3]
MTAVAKLFMNGRSQAVRLPQEFRFKGTEVEIWRDPATGHVILAEKPQRTGSWEKFFAARDALRPEDIPEDFLKDRDQGTQ
ERDDPFA

Download         Length: 264 bp

>AT37114 NZ_AP023262:c2766348-2766085 [Mesorhizobium sp. L-8-3]
ATGACAGCCGTCGCAAAGCTCTTCATGAACGGGCGCAGCCAAGCCGTGCGCCTTCCCCAGGAGTTTCGGTTCAAGGGAAC
GGAAGTGGAGATCTGGCGGGACCCGGCAACGGGACACGTGATCCTGGCAGAGAAGCCGCAGCGGACAGGGTCGTGGGAGA
AGTTCTTTGCCGCGCGGGACGCGCTCAGGCCGGAGGACATTCCCGAAGATTTCCTGAAGGACCGGGACCAGGGGACTCAG
GAGCGGGACGACCCCTTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References