Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 753822..754486 Replicon chromosome
Accession NZ_AP023262
Organism Mesorhizobium sp. L-8-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN302_RS03455 Protein ID WP_202310103.1
Coordinates 753822..754229 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN302_RS03460 Protein ID WP_202331759.1
Coordinates 754226..754486 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN302_RS03435 749449..750372 + 924 WP_202331756.1 ABC transporter permease -
JN302_RS03440 750362..751171 + 810 WP_202331757.1 ABC transporter permease -
JN302_RS03445 751210..752244 + 1035 WP_202310101.1 extracellular solute-binding protein -
JN302_RS03450 752352..753779 + 1428 WP_202331758.1 amidase -
JN302_RS03455 753822..754229 - 408 WP_202310103.1 type II toxin-antitoxin system VapC family toxin Toxin
JN302_RS03460 754226..754486 - 261 WP_202331759.1 antitoxin Antitoxin
JN302_RS03465 754680..755846 - 1167 WP_202310105.1 porin -
JN302_RS03470 756185..756871 + 687 WP_202310106.1 ribulose-phosphate 3-epimerase -
JN302_RS03475 757106..758263 - 1158 WP_202331760.1 N-acetylglucosamine-6-phosphate deacetylase -
JN302_RS03480 758260..759270 - 1011 WP_202334171.1 SIS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(8-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14768.97 Da        Isoelectric Point: 6.4694

>T37110 WP_202310103.1 NZ_AP023262:c754229-753822 [Mesorhizobium sp. L-8-3]
MTNWLLDTNAVIALVTRRSEALMRRVESTEPGALAVSSIVAHELCFGAYRSQKVDFNLETLRLLFADIVILDLDREDARA
AGEIRADLARRGTPIGPHDVLIAGQALARGMPLVTNNTAGFARIAGLRLEDWTRG

Download         Length: 408 bp

>T37110 NZ_AP023262:c754229-753822 [Mesorhizobium sp. L-8-3]
ATGACGAACTGGCTTCTCGATACCAACGCGGTCATCGCCCTTGTAACGCGCCGCTCGGAAGCCCTGATGCGCCGGGTCGA
ATCCACCGAACCCGGCGCGCTCGCCGTCTCCTCGATCGTCGCCCATGAACTCTGCTTCGGCGCCTATCGTAGCCAGAAGG
TGGACTTCAATCTCGAAACGCTCCGTCTGCTCTTCGCCGACATCGTGATCCTCGACCTCGACCGCGAGGACGCGCGGGCC
GCCGGCGAGATCAGGGCTGACCTCGCAAGGCGGGGCACGCCGATCGGCCCCCATGACGTCCTGATCGCCGGCCAGGCGCT
TGCGCGCGGCATGCCGCTCGTCACCAACAATACCGCCGGGTTCGCGCGTATAGCCGGATTGCGGCTGGAAGACTGGACCA
GGGGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9709.95 Da        Isoelectric Point: 8.9127

>AT37110 WP_202331759.1 NZ_AP023262:c754486-754226 [Mesorhizobium sp. L-8-3]
MPHIAKVFQSGNSQAVRLPKDFRFTVDEVEVSREGDAVILRPRPDASRPWASLRAAVERGFSADFMAAGREQPEVQKRPD
LDQAFR

Download         Length: 261 bp

>AT37110 NZ_AP023262:c754486-754226 [Mesorhizobium sp. L-8-3]
ATGCCGCATATCGCCAAGGTCTTCCAGTCCGGCAACTCTCAGGCCGTCAGGCTGCCGAAGGATTTCCGCTTCACGGTCGA
TGAGGTCGAGGTCTCGCGCGAGGGCGACGCTGTGATCCTGCGCCCGAGGCCGGACGCCTCCCGCCCTTGGGCCTCCCTGC
GCGCGGCCGTCGAGCGCGGTTTCAGTGCCGACTTCATGGCCGCGGGCCGGGAACAGCCCGAGGTACAGAAGCGTCCCGAT
CTCGACCAGGCGTTTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References