Detailed information of TA system TA037109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 546767..547371
• Replicon: chromosome
• Accession: NZ_AP023262
• Organism: Mesorhizobium sp. L-8-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JN302_RS02540
• Protein ID: WP_202331551.1
• Coordinates: 547066..547371 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JN302_RS02535
• Protein ID: WP_202314476.1
• Coordinates: 546767..547069 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN302_RS02510	541882..542943	-	1062	WP_202331547.1	agmatinase	-
JN302_RS02515	543059..544033	+	975	WP_202309953.1	transcriptional regulator GcvA	-
JN302_RS02520	544205..545365	+	1161	WP_202331549.1	iron-containing alcohol dehydrogenase	-
JN302_RS02525	545365..545796	+	432	WP_202309955.1	acyl-CoA thioesterase	-
JN302_RS02530	545901..546674	+	774	WP_202309956.1	SH3 domain-containing protein	-
JN302_RS02535	546767..547069	+	303	WP_202314476.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JN302_RS02540	547066..547371	+	306	WP_202331551.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JN302_RS02545	547495..548799	+	1305	WP_202309958.1	nicotinate phosphoribosyltransferase	-
JN302_RS02550	548855..550240	+	1386	WP_202314477.1	hypothetical protein	-
JN302_RS02555	550391..551698	+	1308	WP_202309959.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-55)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11437.11 Da
• Isoelectric Point: 8.6584

>T37109 WP_202331551.1 NZ_AP023262:547066-547371 [Mesorhizobium sp. L-8-3]
VKLVWAQFAVTDRVRIFGHIEADNARAAVRVDEQIARAVRRLLDFPESGRPGRVAGTREMVVPRTPYIAAYVVTSDRIRI
LRVLHGAQIWPDEIADDTDFP

Nucleotide

• Length: 306 bp

>T37109 NZ_AP023262:547066-547371 [Mesorhizobium sp. L-8-3]
GTGAAGCTTGTCTGGGCACAATTTGCCGTTACGGATCGCGTCAGAATCTTCGGCCACATCGAAGCCGACAATGCGAGGGC
AGCGGTTCGAGTAGACGAGCAAATCGCTCGTGCGGTGAGGCGCCTGCTCGATTTTCCCGAAAGCGGACGTCCCGGCCGGG
TCGCAGGAACACGCGAGATGGTTGTACCTCGCACGCCCTACATCGCTGCCTATGTCGTGACGTCCGACAGGATTCGCATC
TTGCGTGTCCTCCACGGAGCACAGATCTGGCCGGACGAGATTGCCGACGACACCGATTTTCCGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10917.33 Da
• Isoelectric Point: 4.5141

>AT37109 WP_202314476.1 NZ_AP023262:546767-547069 [Mesorhizobium sp. L-8-3]
MVSNALIQTRIDADIKDRATAVLENMGLTVSDAVRILLTRTANEGALPLELVTNSEAHDAWFRAKVLQALEDARPDVDDD
EAETQFVARRLAALGKTGKQ

Nucleotide

• Length: 303 bp

>AT37109 NZ_AP023262:546767-547069 [Mesorhizobium sp. L-8-3]
ATGGTTTCAAACGCACTGATCCAGACACGCATCGACGCCGATATAAAGGACCGCGCGACGGCTGTGCTCGAGAACATGGG
CCTCACGGTCTCCGATGCTGTCCGCATTCTGCTGACACGTACCGCGAACGAAGGCGCCTTGCCGCTCGAACTCGTCACCA
ACAGCGAGGCCCATGATGCCTGGTTCCGCGCAAAGGTCCTGCAGGCGCTTGAGGATGCGCGGCCGGACGTGGACGACGAC
GAAGCGGAGACGCAGTTTGTGGCCCGACGGCTGGCCGCTTTGGGCAAGACCGGCAAACAGTGA