Detailed information of TA system TA037108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 350916..351610
• Replicon: chromosome
• Accession: NZ_AP023262
• Organism: Mesorhizobium sp. L-8-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JN302_RS01595
• Protein ID: WP_202309804.1
• Coordinates: 351188..351610 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JN302_RS01590
• Protein ID: WP_202309803.1
• Coordinates: 350916..351191 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JN302_RS01560	346332..346628	-	297	WP_202331363.1	antibiotic biosynthesis monooxygenase	-
JN302_RS01565	346644..347714	-	1071	WP_202331364.1	heat-inducible transcriptional repressor HrcA	-
JN302_RS01570	347876..348592	+	717	WP_202331365.1	ribonuclease PH	-
JN302_RS01575	348606..349016	+	411	WP_202331366.1	VOC family protein	-
JN302_RS01580	349016..349663	+	648	WP_202331367.1	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase	-
JN302_RS01585	349660..350823	+	1164	WP_202331368.1	coproporphyrinogen III oxidase	-
JN302_RS01590	350916..351191	+	276	WP_202309803.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JN302_RS01595	351188..351610	+	423	WP_202309804.1	type II toxin-antitoxin system VapC family toxin	Toxin
JN302_RS01600	351723..352622	+	900	WP_202331369.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
JN302_RS01605	352612..352977	+	366	WP_202331370.1	YraN family protein	-
JN302_RS01610	353054..353878	+	825	WP_202331371.1	cyclase family protein	-
JN302_RS01615	353961..355331	-	1371	Protein_321	cytochrome P450	-
JN302_RS01620	355566..356135	+	570	WP_202331372.1	NAD(P)H-dependent oxidoreductase	-
JN302_RS01625	356165..356497	-	333	WP_202331373.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (13-78)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15671.99 Da
• Isoelectric Point: 4.7790

>T37108 WP_202309804.1 NZ_AP023262:351188-351610 [Mesorhizobium sp. L-8-3]
VSYLLDTNVLSEVRRPAPSPKVLAWLDEVDEDRSFISVISLAELRRGVLLMDDGRRREALAAWLVHDLPDRFAGRILPID
PETAERWGDLMAESQKIGRALSTMDGFLAATALGRQLTLVTRNTKDFASFGVPLLNPWEL

Nucleotide

• Length: 423 bp

>T37108 NZ_AP023262:351188-351610 [Mesorhizobium sp. L-8-3]
GTGAGCTACCTGCTGGATACCAACGTCCTGTCTGAAGTCCGACGTCCGGCGCCAAGCCCAAAGGTTCTCGCCTGGCTCGA
TGAAGTCGATGAGGACAGGTCGTTCATAAGCGTCATTTCACTCGCTGAGCTTCGTCGTGGCGTTCTCCTGATGGACGATG
GGCGACGAAGGGAGGCGCTCGCTGCCTGGCTGGTGCATGATCTCCCCGACCGTTTCGCCGGCCGGATCCTACCAATCGAC
CCTGAGACCGCCGAGCGATGGGGAGATCTCATGGCCGAAAGCCAGAAGATCGGAAGGGCGCTTTCAACGATGGACGGGTT
CCTGGCCGCGACCGCACTGGGCAGGCAACTCACTCTGGTGACGCGAAACACCAAGGACTTCGCGTCCTTTGGGGTTCCTC
TTCTCAACCCATGGGAGCTGTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9931.22 Da
• Isoelectric Point: 7.2053

>AT37108 WP_202309803.1 NZ_AP023262:350916-351191 [Mesorhizobium sp. L-8-3]
MTTPETGPAEAATWTLARAKAKLSEVVDRAQAEPQLITRNGKPSAVIVSAEEWARKTTRKGSLADFLLNSPLRGTDIEID
RHHDAPRDIAL

Nucleotide

• Length: 276 bp

>AT37108 NZ_AP023262:350916-351191 [Mesorhizobium sp. L-8-3]
ATGACTACGCCTGAGACAGGCCCGGCCGAAGCTGCAACGTGGACTCTGGCGCGGGCAAAGGCAAAGCTCTCCGAGGTCGT
TGACCGCGCCCAGGCTGAGCCCCAGTTGATCACACGCAACGGCAAGCCGAGTGCGGTGATCGTCTCAGCCGAAGAATGGG
CGCGCAAGACAACGCGCAAGGGAAGCCTTGCCGACTTCCTGCTCAATTCACCATTGCGTGGCACCGATATTGAGATAGAT
CGGCATCACGACGCACCGCGTGACATAGCTCTGTGA