Detailed information of TA system TA037103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2871183..2871868
• Replicon: chromosome
• Accession: NZ_AP023257
• Organism: Mesorhizobium sp. L-2-11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JG739_RS13795
• Protein ID: WP_202366918.1
• Coordinates: 2871443..2871868 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JG739_RS13790
• Protein ID: WP_202366917.1
• Coordinates: 2871183..2871443 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG739_RS13760	2866390..2867172	+	783	WP_202367458.1	ATP-binding cassette domain-containing protein	-
JG739_RS13765	2867189..2868370	+	1182	WP_202366913.1	aldose 1-epimerase family protein	-
JG739_RS13770	2868462..2869550	+	1089	WP_202366914.1	fatty acid desaturase family protein	-
JG739_RS13775	2869594..2869905	+	312	WP_128180732.1	Rieske 2Fe-2S domain-containing protein	-
JG739_RS13780	2870019..2870819	+	801	WP_202366915.1	3-methyl-2-oxobutanoate hydroxymethyltransferase	-
JG739_RS13785	2870794..2871042	-	249	WP_202366916.1	hypothetical protein	-
JG739_RS13790	2871183..2871443	+	261	WP_202366917.1	Arc family DNA-binding protein	Antitoxin
JG739_RS13795	2871443..2871868	+	426	WP_202366918.1	type II toxin-antitoxin system VapC family toxin	Toxin
JG739_RS13800	2871872..2872759	-	888	WP_202367459.1	amidohydrolase	-
JG739_RS13805	2872759..2873895	-	1137	WP_202366919.1	VWA domain-containing protein	-
JG739_RS13810	2874140..2875036	-	897	WP_202366920.1	MoxR family ATPase	-
JG739_RS13815	2875046..2876050	-	1005	WP_202366921.1	molybdopterin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15376.43 Da
• Isoelectric Point: 4.7352

>T37103 WP_202366918.1 NZ_AP023257:2871443-2871868 [Mesorhizobium sp. L-2-11]
MILLDTNVISEAMRDTNNGRVIDWIDAQSVETLYLAAITVAELRLGIAVLPAGKRRDRIRARLEQEVLPVFAGRVLPFDM
ETSETYANLMAHARGMGRAIDRADGYIAATAASHGYSVATRDTSPFEAAGVAVINPWDESN

Nucleotide

• Length: 426 bp

>T37103 NZ_AP023257:2871443-2871868 [Mesorhizobium sp. L-2-11]
ATGATCCTCCTAGATACGAACGTCATTTCGGAGGCAATGCGGGATACGAACAATGGCCGCGTCATCGATTGGATCGACGC
GCAGTCCGTCGAGACGCTTTATCTGGCGGCGATCACTGTAGCCGAGCTGCGCCTTGGCATTGCAGTGCTGCCTGCCGGTA
AGCGTCGAGACAGGATTCGCGCGCGGCTTGAGCAGGAAGTGTTGCCGGTGTTCGCCGGGCGTGTCCTGCCGTTCGACATG
GAGACCTCGGAGACCTATGCAAACCTTATGGCACATGCGCGGGGGATGGGCAGGGCCATTGATAGAGCTGACGGGTATAT
CGCCGCCACAGCGGCCTCCCACGGTTATTCAGTCGCCACGCGCGACACGTCTCCTTTCGAGGCAGCAGGCGTGGCGGTCA
TAAATCCGTGGGACGAATCCAACTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9765.06 Da
• Isoelectric Point: 5.7544

>AT37103 WP_202366917.1 NZ_AP023257:2871183-2871443 [Mesorhizobium sp. L-2-11]
MPAITIRNLPVETHRALKMRAAQHGRSTEAEIRDILENATRPEGRIKLGSLLAEIGREARLTDEEWASFEATLERDKTPA
EPIRFD

Nucleotide

• Length: 261 bp

>AT37103 NZ_AP023257:2871183-2871443 [Mesorhizobium sp. L-2-11]
ATGCCGGCGATCACGATACGGAATCTGCCCGTTGAGACGCATCGTGCTCTCAAGATGCGCGCCGCCCAACACGGGCGCAG
TACCGAGGCCGAAATCCGTGACATCTTGGAAAATGCGACAAGACCAGAAGGGCGGATCAAGCTGGGTTCTCTTCTGGCCG
AAATCGGTCGCGAGGCGAGACTGACCGACGAGGAATGGGCTTCATTCGAGGCCACACTTGAGCGCGACAAGACGCCAGCC
GAGCCGATCAGGTTCGACTGA