Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2222646..2223298 Replicon chromosome
Accession NZ_AP023257
Organism Mesorhizobium sp. L-2-11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JG739_RS10695 Protein ID WP_202366433.1
Coordinates 2222646..2223035 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JG739_RS10700 Protein ID WP_202366434.1
Coordinates 2223032..2223298 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG739_RS10665 2217848..2218465 - 618 WP_202366427.1 TetR/AcrR family transcriptional regulator -
JG739_RS10670 2218533..2218955 + 423 WP_202366428.1 VOC family protein -
JG739_RS10675 2219066..2219977 + 912 WP_202366429.1 arginase family protein -
JG739_RS10680 2219981..2220931 - 951 WP_202366430.1 trypsin-like peptidase domain-containing protein -
JG739_RS10685 2221108..2221980 + 873 WP_202366431.1 S1C family serine protease -
JG739_RS10690 2221989..2222639 + 651 WP_202366432.1 helix-turn-helix transcriptional regulator -
JG739_RS10695 2222646..2223035 - 390 WP_202366433.1 type II toxin-antitoxin system VapC family toxin Toxin
JG739_RS10700 2223032..2223298 - 267 WP_202366434.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JG739_RS10705 2223464..2224330 + 867 WP_202366435.1 NAD(P)-dependent oxidoreductase -
JG739_RS10710 2224596..2226785 - 2190 WP_202367406.1 OmpA family protein -
JG739_RS10715 2226997..2227443 + 447 WP_202367407.1 YcgN family cysteine cluster protein -
JG739_RS10720 2227686..2228048 + 363 WP_202366436.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14347.64 Da        Isoelectric Point: 5.7222

>T37102 WP_202366433.1 NZ_AP023257:c2223035-2222646 [Mesorhizobium sp. L-2-11]
MIIDSSALVAILRTEPGYDRLVLAIAQAERRLLAAPTLLETTMVLVGRWQDQIVDRFEAFLRTASIETIPFTADHAAVAR
QAFLRYGKGRHPAALNFGDCIAYATARLEAMPLLFKSDDFRLTDIEPAL

Download         Length: 390 bp

>T37102 NZ_AP023257:c2223035-2222646 [Mesorhizobium sp. L-2-11]
ATGATCATCGACTCCTCTGCCCTCGTCGCTATTTTGCGCACGGAACCAGGCTATGATCGTTTGGTGCTGGCGATCGCTCA
GGCTGAAAGGCGGCTGCTCGCGGCACCGACCCTGCTTGAGACGACGATGGTGCTGGTCGGCCGCTGGCAAGACCAGATCG
TCGACCGCTTCGAAGCCTTTTTGCGCACCGCATCGATCGAGACGATCCCTTTTACGGCCGACCATGCCGCTGTGGCCCGT
CAGGCCTTCCTGCGCTATGGCAAAGGCCGGCATCCGGCCGCCTTAAATTTCGGCGACTGCATCGCCTATGCCACGGCCCG
TCTCGAAGCCATGCCACTGCTGTTCAAGAGCGACGATTTCCGGCTGACGGATATCGAACCGGCTTTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10150.54 Da        Isoelectric Point: 4.7503

>AT37102 WP_202366434.1 NZ_AP023257:c2223298-2223032 [Mesorhizobium sp. L-2-11]
MALSIKNTEVEQLARELARRRRVSVTEAIRQSLEREVARERLVPRDEADDLFQRLMAIAETAAQIPKRQDAMTEDEILGY
DELGIPTR

Download         Length: 267 bp

>AT37102 NZ_AP023257:c2223298-2223032 [Mesorhizobium sp. L-2-11]
ATGGCCCTGTCGATCAAGAACACCGAAGTCGAGCAATTGGCGCGGGAACTTGCCCGCCGTCGTCGCGTGTCGGTGACGGA
AGCGATCCGTCAAAGCCTCGAGCGCGAAGTTGCGCGCGAGCGGCTTGTGCCGCGCGACGAGGCCGACGACCTTTTTCAGC
GCCTGATGGCAATCGCCGAAACAGCCGCACAGATACCGAAACGCCAAGATGCGATGACCGAAGACGAAATCCTCGGCTAT
GACGAACTTGGAATCCCGACGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References