Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1016768..1017423 Replicon chromosome
Accession NZ_AP023257
Organism Mesorhizobium sp. L-2-11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JG739_RS04800 Protein ID WP_202365483.1
Coordinates 1016768..1017169 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JG739_RS04805 Protein ID WP_202365484.1
Coordinates 1017169..1017423 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG739_RS04775 1011790..1012062 + 273 WP_202365478.1 usg protein -
JG739_RS04780 1012235..1013269 - 1035 WP_202365479.1 aldo/keto reductase -
JG739_RS04785 1013309..1014487 - 1179 WP_202365480.1 MFS transporter -
JG739_RS04790 1014625..1015533 + 909 WP_202365481.1 LysR family transcriptional regulator -
JG739_RS04795 1015583..1016632 - 1050 WP_202365482.1 aldo/keto reductase -
JG739_RS04800 1016768..1017169 - 402 WP_202365483.1 type II toxin-antitoxin system VapC family toxin Toxin
JG739_RS04805 1017169..1017423 - 255 WP_202365484.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JG739_RS04810 1017510..1018172 - 663 WP_202365485.1 YggS family pyridoxal phosphate-dependent enzyme -
JG739_RS04815 1018320..1020944 + 2625 WP_202365486.1 leucine--tRNA ligase -
JG739_RS04820 1020931..1021518 + 588 WP_202365487.1 hypothetical protein -
JG739_RS04825 1021611..1022264 - 654 WP_202365488.1 fructose-6-phosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14835.95 Da        Isoelectric Point: 4.9161

>T37100 WP_202365483.1 NZ_AP023257:c1017169-1016768 [Mesorhizobium sp. L-2-11]
MYLLDTNIVSDVERRLPNPTAWLASVDPASVNLSVITLGEIERGIVKLRKVDPERATRLDLWLRELRRDNADRILAVTEE
VALSWGRISAGRTRGSADTLIAATAFVHDLILVTRNVTDFDDTGVTVLNPWTI

Download         Length: 402 bp

>T37100 NZ_AP023257:c1017169-1016768 [Mesorhizobium sp. L-2-11]
ATGTACCTGCTCGACACGAACATAGTTTCGGATGTGGAACGACGCTTGCCCAATCCGACCGCCTGGCTGGCTTCGGTGGA
TCCGGCTTCGGTCAATCTCAGTGTCATCACGCTTGGGGAGATCGAACGCGGGATCGTCAAGCTGCGCAAGGTCGATCCCG
AACGGGCAACACGCCTCGATCTGTGGTTGCGAGAGCTTCGGCGCGACAATGCCGACCGCATCCTTGCGGTTACTGAAGAA
GTAGCGTTGTCGTGGGGTCGCATTTCGGCTGGCCGCACACGCGGCAGCGCCGACACGCTGATCGCCGCCACAGCTTTTGT
CCACGACCTCATTCTGGTTACGCGCAACGTCACCGACTTCGACGATACCGGGGTGACGGTCCTCAATCCTTGGACAATCT
GA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9608.79 Da        Isoelectric Point: 7.0129

>AT37100 WP_202365484.1 NZ_AP023257:c1017423-1017169 [Mesorhizobium sp. L-2-11]
MAWHLQDAKNNFSKVVQRARSEGPQTVTLRGKRAAVVLSAEDYDRLSGKRKSLAEYLLTGPVWDDDFAEEVNRRSDTMIR
DIDL

Download         Length: 255 bp

>AT37100 NZ_AP023257:c1017423-1017169 [Mesorhizobium sp. L-2-11]
ATGGCCTGGCATCTTCAGGATGCGAAAAACAACTTTTCCAAAGTGGTTCAGCGCGCGCGCAGCGAGGGGCCGCAGACGGT
GACCCTGCGTGGCAAGCGCGCGGCCGTGGTGCTTTCTGCCGAAGACTATGACCGCTTGTCGGGAAAAAGGAAGTCACTGG
CAGAATATCTTCTGACCGGTCCCGTCTGGGATGATGATTTCGCCGAGGAGGTCAACCGTCGCTCGGATACAATGATCCGC
GACATCGACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References