Detailed information of TA system TA037099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 297480..298282
• Replicon: chromosome
• Accession: NZ_AP023257
• Organism: Mesorhizobium sp. L-2-11

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: JG739_RS01365
• Protein ID: WP_202364908.1
• Coordinates: 297755..298282 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: JG739_RS01360
• Protein ID: WP_202364907.1
• Coordinates: 297480..297758 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG739_RS01330	293070..293435	+	366	WP_202364903.1	hypothetical protein	-
JG739_RS01335	293407..293814	-	408	WP_202364904.1	DUF2000 family protein	-
JG739_RS01340	293850..294728	+	879	WP_202364905.1	AraC family transcriptional regulator	-
JG739_RS01345	294745..295215	-	471	WP_023796815.1	MarR family winged helix-turn-helix transcriptional regulator	-
JG739_RS01350	295423..296155	-	733	Protein_266	intradiol ring-cleavage dioxygenase	-
JG739_RS01355	296340..297404	+	1065	WP_202364906.1	GTP-binding protein	-
JG739_RS01360	297480..297758	+	279	WP_202364907.1	DUF1778 domain-containing protein	Antitoxin
JG739_RS01365	297755..298282	+	528	WP_202364908.1	GNAT family N-acetyltransferase	Toxin
JG739_RS01370	298402..299376	+	975	WP_202364909.1	WD40 repeat domain-containing protein	-
JG739_RS01375	299431..300813	+	1383	WP_202364910.1	aspartate aminotransferase family protein	-
JG739_RS01380	300827..302248	+	1422	WP_202367295.1	glutamine synthetase family protein	-
JG739_RS01385	302369..303058	+	690	WP_202364911.1	UdgX family uracil-DNA binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (34-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (12-87)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18769.41 Da
• Isoelectric Point: 8.7249

>T37099 WP_202364908.1 NZ_AP023257:297755-298282 [Mesorhizobium sp. L-2-11]
VTLPFWHEESIAKRHDRASFDCGDAQMNDFLRRFARQAHDQNAAKTFCAIDNAASDRVLGFYTIAPSAVAHETVPDAMTR
GLARHEVSGYKLARLATDRAVAGQGLGGQLLAAAALRCLRLAGEGGGILLIIDAKNERAARWYASYGAESLQGQVLTLAM
PLATFATGLRAKGLL

Nucleotide

• Length: 528 bp

>T37099 NZ_AP023257:297755-298282 [Mesorhizobium sp. L-2-11]
GTGACGCTTCCGTTCTGGCACGAGGAGTCGATTGCGAAACGGCACGATAGGGCTTCTTTCGATTGCGGTGATGCTCAGAT
GAACGATTTTCTGCGGCGGTTCGCACGGCAGGCCCACGATCAGAACGCGGCCAAGACCTTCTGTGCAATCGACAACGCGG
CTTCGGATCGGGTGCTCGGTTTCTATACAATCGCCCCTTCCGCTGTAGCTCATGAAACAGTGCCCGACGCCATGACGAGA
GGCTTGGCGCGACACGAGGTTTCCGGCTACAAGCTTGCCCGTCTTGCGACCGACCGCGCCGTCGCCGGGCAAGGGCTCGG
AGGTCAGCTGCTAGCCGCCGCAGCGTTGCGGTGCCTGCGGCTTGCAGGTGAGGGCGGCGGCATTCTGCTCATCATCGACG
CCAAGAACGAGCGGGCAGCACGGTGGTATGCCAGCTATGGAGCCGAGAGCCTCCAAGGCCAGGTTTTGACCCTGGCGATG
CCATTGGCGACCTTCGCAACTGGTCTGCGGGCCAAGGGACTGCTTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10208.86 Da
• Isoelectric Point: 9.9201

>AT37099 WP_202364907.1 NZ_AP023257:297480-297758 [Mesorhizobium sp. L-2-11]
MSRSADNKTERYQIRIPPAQKAMIARAAALSHKDMADFILDKIVPEAQAVIESAEVMRVSNRDFARILELLENPPKPNAR
LRAAIAALPDSL

Nucleotide

• Length: 279 bp

>AT37099 NZ_AP023257:297480-297758 [Mesorhizobium sp. L-2-11]
ATGTCCAGATCCGCCGACAATAAAACCGAACGTTATCAGATACGCATTCCGCCGGCGCAGAAGGCGATGATCGCCCGTGC
AGCGGCGCTGTCGCATAAGGACATGGCCGACTTCATCCTCGACAAGATCGTACCCGAAGCGCAGGCCGTGATCGAATCTG
CCGAGGTGATGAGGGTGTCCAACCGCGACTTCGCACGCATCCTTGAACTCCTTGAGAACCCGCCGAAACCCAATGCCAGG
CTGCGAGCGGCGATCGCTGCCTTGCCCGATAGTCTGTGA