Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3405842..3406608 Replicon chromosome
Accession NZ_AP023249
Organism Mesorhizobium sp. 131-2-5

Toxin (Protein)


Gene name tacT Uniprot ID A0A6M7TS52
Locus tag JG740_RS16820 Protein ID WP_064984294.1
Coordinates 3406123..3406608 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6M7TJG1
Locus tag JG740_RS16815 Protein ID WP_064983733.1
Coordinates 3405842..3406123 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG740_RS16790 3401195..3402175 + 981 WP_064983728.1 ABC transporter permease -
JG740_RS16795 3402172..3403158 + 987 WP_019859204.1 ABC transporter permease -
JG740_RS16800 3403275..3403823 + 549 WP_064983730.1 gluconokinase -
JG740_RS16805 3403910..3404359 - 450 WP_019859201.1 Rrf2 family transcriptional regulator -
JG740_RS16810 3404609..3405595 - 987 WP_064983732.1 sulfate ABC transporter substrate-binding protein -
JG740_RS16815 3405842..3406123 + 282 WP_064983733.1 DUF1778 domain-containing protein Antitoxin
JG740_RS16820 3406123..3406608 + 486 WP_064984294.1 GNAT family N-acetyltransferase Toxin
JG740_RS16825 3406661..3407701 - 1041 WP_064983735.1 sulfate/molybdate ABC transporter ATP-binding protein -
JG740_RS16830 3407771..3408655 - 885 WP_019859196.1 sulfate ABC transporter permease subunit CysW -
JG740_RS16835 3408648..3409499 - 852 WP_019859195.1 sulfate ABC transporter permease subunit CysT -
JG740_RS16840 3409584..3410612 - 1029 WP_019859193.1 sulfate ABC transporter substrate-binding protein -
JG740_RS16845 3410817..3411548 - 732 WP_019859191.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(3-79)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17185.84 Da        Isoelectric Point: 9.4412

>T37092 WP_064984294.1 NZ_AP023249:3406123-3406608 [Mesorhizobium sp. 131-2-5]
MLSAPAPLAENHDLELFQSGTESLDQWLRRRARANQVGGASRTYVVAEGARVVGYYCLSSGGLDLAEAPGPIRRNMPDPI
PMVVLGRLAVDAGWQGKGLGAALLQDAVLRAGHAATILRIRGIFVHAISDEAKAFYEHYGFAASPKHPMTLVLSLKGLVK
A

Download         Length: 486 bp

>T37092 NZ_AP023249:3406123-3406608 [Mesorhizobium sp. 131-2-5]
ATGCTATCGGCGCCGGCGCCCCTGGCCGAAAACCACGATCTCGAACTTTTCCAAAGTGGGACTGAAAGCCTCGACCAATG
GCTGCGCCGTAGGGCGCGGGCCAACCAAGTCGGTGGCGCGTCTCGGACTTATGTGGTGGCGGAAGGCGCTCGGGTTGTCG
GCTATTACTGCCTGTCTTCGGGCGGGCTTGATCTTGCGGAGGCGCCTGGCCCCATCCGTCGCAACATGCCGGATCCCATC
CCAATGGTCGTACTCGGGCGCCTTGCCGTGGACGCAGGCTGGCAAGGCAAGGGGCTGGGTGCCGCGCTACTGCAAGACGC
CGTTCTGCGCGCCGGCCACGCCGCGACGATCCTCAGGATTCGCGGCATTTTCGTTCATGCCATATCGGATGAGGCGAAAG
CCTTCTACGAGCACTACGGCTTCGCGGCTTCTCCGAAGCATCCAATGACCTTGGTGCTATCGTTGAAGGGCCTGGTGAAA
GCTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10709.28 Da        Isoelectric Point: 8.5038

>AT37092 WP_064983733.1 NZ_AP023249:3405842-3406123 [Mesorhizobium sp. 131-2-5]
MTKAAPENHAKPVNLRIREDMRILIDRAAKIRGKTRSDFMIDAAYRSAEETLLDQTLIKVDPESYRHYLDILDKPPSGEG
FARLMNAPKPWQD

Download         Length: 282 bp

>AT37092 NZ_AP023249:3405842-3406123 [Mesorhizobium sp. 131-2-5]
ATGACAAAGGCCGCCCCTGAGAACCACGCCAAGCCTGTCAATCTGCGTATCCGAGAGGACATGCGCATACTAATTGACCG
CGCCGCGAAAATACGCGGGAAAACCCGCTCCGACTTCATGATCGACGCCGCCTACCGTTCGGCTGAGGAGACGCTGCTCG
ACCAGACCCTGATCAAGGTGGATCCGGAGAGTTACCGGCATTATCTCGACATCCTTGACAAACCGCCAAGCGGGGAGGGT
TTTGCGCGCCTTATGAACGCGCCCAAGCCATGGCAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M7TS52

Antitoxin

Source ID Structure
AlphaFold DB A0A6M7TJG1

References