Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4708454..4709127 Replicon chromosome
Accession NZ_AP023247
Organism Mesorhizobium sp. 131-2-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JG743_RS23030 Protein ID WP_202293010.1
Coordinates 4708454..4708876 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JG743_RS23035 Protein ID WP_202293011.1
Coordinates 4708873..4709127 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG743_RS22995 4704242..4704601 - 360 WP_127422875.1 metalloregulator ArsR/SmtB family transcription factor -
JG743_RS23000 4705041..4705286 + 246 WP_127399939.1 DUF982 domain-containing protein -
JG743_RS23010 4705492..4705797 - 306 WP_126055558.1 ETC complex I subunit -
JG743_RS23015 4706117..4707292 + 1176 WP_202302907.1 NAD(P)/FAD-dependent oxidoreductase -
JG743_RS23025 4707563..4708273 + 711 WP_202293009.1 hypothetical protein -
JG743_RS23030 4708454..4708876 - 423 WP_202293010.1 type II toxin-antitoxin system VapC family toxin Toxin
JG743_RS23035 4708873..4709127 - 255 WP_202293011.1 Arc family DNA-binding protein Antitoxin
JG743_RS23040 4709211..4709915 - 705 WP_202293012.1 hypothetical protein -
JG743_RS23045 4709922..4711124 - 1203 WP_202293013.1 AI-2E family transporter -
JG743_RS23050 4711096..4711653 - 558 WP_202293014.1 CDP-alcohol phosphatidyltransferase family protein -
JG743_RS23055 4711906..4712985 + 1080 WP_202293015.1 phosphoribosylformylglycinamidine cyclo-ligase -
JG743_RS23060 4712982..4713689 + 708 WP_202293016.1 phosphoribosylglycinamide formyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14867.99 Da        Isoelectric Point: 5.0859

>T37090 WP_202293010.1 NZ_AP023247:c4708876-4708454 [Mesorhizobium sp. 131-2-1]
MILLDTNVVSEVMRPEPHPAVLAWLDDQVAETLYISSVTLAEVLFGIEVMPAGRRRNVLAEAFAGIYAVFDQRVLAFDAQ
AARQYAGLAATARTAGKGFPVPDGYIAAIAAARGFHVASRDTSAFHAAGIPVVNPWESAA

Download         Length: 423 bp

>T37090 NZ_AP023247:c4708876-4708454 [Mesorhizobium sp. 131-2-1]
ATGATCCTCCTGGACACCAATGTCGTTTCGGAGGTGATGAGGCCGGAACCCCATCCGGCGGTGCTGGCATGGCTGGACGA
TCAGGTTGCTGAAACATTGTATATTTCCAGCGTCACGCTTGCTGAGGTGCTGTTCGGTATCGAGGTGATGCCAGCGGGCC
GCCGCAGGAACGTCCTGGCTGAGGCCTTTGCCGGCATATACGCAGTGTTCGATCAGCGCGTTCTGGCATTCGATGCACAA
GCAGCGCGTCAGTATGCCGGCCTTGCCGCAACGGCCAGAACCGCTGGCAAGGGGTTTCCCGTACCCGATGGCTACATAGC
GGCGATCGCCGCCGCAAGGGGCTTCCACGTCGCTTCGCGCGACACGTCGGCCTTTCATGCGGCAGGCATACCAGTCGTCA
ATCCTTGGGAAAGTGCGGCGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9338.58 Da        Isoelectric Point: 7.2078

>AT37090 WP_202293011.1 NZ_AP023247:c4709127-4708873 [Mesorhizobium sp. 131-2-1]
MTAVTIRNLPEETHRALRVRAALHGRSTEAEIRAILENAVRPEGRVRLGSLVSEIARRAGVKDEDVDALEQARDKGPAEP
LRFE

Download         Length: 255 bp

>AT37090 NZ_AP023247:c4709127-4708873 [Mesorhizobium sp. 131-2-1]
ATGACAGCGGTGACCATTCGAAATCTGCCGGAAGAAACCCACCGCGCTTTGCGCGTGCGCGCCGCCTTGCATGGTCGCAG
CACCGAGGCGGAAATCAGGGCCATACTCGAGAACGCCGTGCGCCCGGAAGGGCGTGTGAGGTTGGGCTCTTTGGTGTCCG
AAATCGCCCGCCGCGCCGGCGTGAAGGACGAGGATGTCGATGCCCTGGAGCAGGCCCGCGATAAAGGCCCGGCCGAGCCT
CTGAGGTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References