Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 540836..541518 Replicon chromosome
Accession NZ_AP023246
Organism Mesorhizobium sp. 113-3-9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MesoLj_RS02480 Protein ID WP_202324965.1
Coordinates 541096..541518 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MesoLj_RS02475 Protein ID WP_202327142.1
Coordinates 540836..541099 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MesoLj_RS02450 535907..536848 + 942 WP_140770393.1 sugar ABC transporter substrate-binding protein -
MesoLj_RS02455 536957..538033 + 1077 WP_140770395.1 ABC transporter permease -
MesoLj_RS02460 538036..538803 + 768 WP_027040720.1 sugar ABC transporter ATP-binding protein -
MesoLj_RS02465 538928..539923 + 996 WP_202324963.1 inositol 2-dehydrogenase -
MesoLj_RS02470 539956..540750 + 795 WP_202324964.1 SDR family oxidoreductase -
MesoLj_RS02475 540836..541099 + 264 WP_202327142.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MesoLj_RS02480 541096..541518 + 423 WP_202324965.1 type II toxin-antitoxin system VapC family toxin Toxin
MesoLj_RS02485 541490..541837 + 348 WP_202324966.1 hypothetical protein -
MesoLj_RS02490 542047..543138 + 1092 WP_202324967.1 3-deoxy-7-phosphoheptulonate synthase -
MesoLj_RS02495 543346..543981 - 636 WP_140770407.1 LysE family translocator -
MesoLj_RS02500 544111..544806 + 696 WP_202324968.1 YafY family transcriptional regulator -
MesoLj_RS02505 544819..545928 - 1110 WP_202324969.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-69)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15650.84 Da        Isoelectric Point: 4.4773

>T37086 WP_202324965.1 NZ_AP023246:541096-541518 [Mesorhizobium sp. 113-3-9]
VRLLLDTNVLSEVTRPAPDARVLDWLDGLDEDRSFISVVSIAEIRRGVALMDEGRKREALAEWLARDLPQRFEQRILPVD
EPVALAWGDLMGLAKRRGRGLSSMDGLIAATAIAQEFTLATRNTRDFEGFGVDLFDPWTA

Download         Length: 423 bp

>T37086 NZ_AP023246:541096-541518 [Mesorhizobium sp. 113-3-9]
GTGAGGCTGCTGCTCGATACGAATGTCCTGTCCGAGGTGACAAGGCCGGCGCCAGACGCGCGCGTTCTGGACTGGCTCGA
CGGGCTTGATGAGGATCGCTCATTCATCAGTGTCGTGTCGATCGCCGAGATCCGGCGTGGCGTCGCCCTCATGGACGAGG
GCCGGAAACGCGAGGCTCTGGCCGAATGGCTCGCCCGGGACCTGCCGCAGCGTTTCGAGCAAAGGATTTTGCCCGTGGAC
GAGCCGGTTGCTTTGGCCTGGGGCGACCTTATGGGCCTTGCGAAGCGTCGCGGTCGCGGCCTGTCGTCGATGGACGGCTT
GATCGCAGCCACGGCGATTGCGCAGGAGTTCACTTTGGCAACGCGCAATACGAGAGACTTCGAAGGATTTGGAGTTGACC
TCTTCGATCCCTGGACTGCTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9693.06 Da        Isoelectric Point: 10.0862

>AT37086 WP_202327142.1 NZ_AP023246:540836-541099 [Mesorhizobium sp. 113-3-9]
MLPAPKDTNWTVAGAKARLSEVIERAQSSPQTITKNGKPSVVVVSAEEWQRKTVRKGTLAQFLLESPLRGADLDLERQRD
EPRDLPL

Download         Length: 264 bp

>AT37086 NZ_AP023246:540836-541099 [Mesorhizobium sp. 113-3-9]
ATGCTGCCTGCACCCAAAGACACGAACTGGACGGTCGCTGGGGCAAAGGCTCGGCTCTCGGAGGTTATCGAGCGCGCGCA
GTCTTCTCCGCAGACGATCACCAAAAACGGCAAACCAAGCGTGGTTGTCGTCTCGGCCGAGGAATGGCAGCGAAAGACCG
TGCGCAAGGGTACGCTTGCGCAGTTCCTGCTGGAGTCACCGCTGCGCGGCGCCGATCTCGACCTTGAGCGCCAGCGTGAC
GAACCGCGTGACCTGCCGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References