Detailed information of TA system TA037083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 4729666..4730264
• Replicon: chromosome
• Accession: NZ_AP023243
• Organism: Mesorhizobium sp. 113-3-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JG746_RS23220
• Protein ID: WP_202354843.1
• Coordinates: 4729887..4730264 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JG746_RS23215
• Protein ID: WP_202354842.1
• Coordinates: 4729666..4729890 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG746_RS23185	4724731..4725543	+	813	WP_202354837.1	metal ABC transporter ATP-binding protein	-
JG746_RS23190	4725543..4726418	+	876	WP_202354838.1	metal ABC transporter permease	-
JG746_RS23195	4726448..4727389	+	942	WP_202354839.1	metal ABC transporter substrate-binding protein	-
JG746_RS23200	4727540..4727878	+	339	WP_202354840.1	TIGR01244 family phosphatase	-
JG746_RS23205	4727875..4728342	-	468	WP_032933331.1	Lrp/AsnC family transcriptional regulator	-
JG746_RS23210	4728480..4729595	+	1116	WP_202354841.1	4-hydroxyphenylpyruvate dioxygenase	-
JG746_RS23215	4729666..4729890	+	225	WP_202354842.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JG746_RS23220	4729887..4730264	+	378	WP_202354843.1	type II toxin-antitoxin system VapC family toxin	Toxin
JG746_RS23225	4730282..4730818	-	537	WP_202354844.1	DinB family protein	-
JG746_RS23230	4730815..4731111	-	297	WP_202354845.1	hypothetical protein	-
JG746_RS23235	4731120..4732133	-	1014	WP_202354846.1	fumarylacetoacetate hydrolase family protein	-
JG746_RS23240	4732130..4733032	-	903	WP_202354847.1	MBL fold metallo-hydrolase	-
JG746_RS23245	4733029..4734342	-	1314	WP_202354848.1	homogentisate 1,2-dioxygenase	-
JG746_RS23250	4734456..4734899	+	444	WP_202354849.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (7-124)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-42)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13707.73 Da
• Isoelectric Point: 6.6035

>T37083 WP_202354843.1 NZ_AP023243:4729887-4730264 [Mesorhizobium sp. 113-3-3]
MTVGAFLADTHIILWSISDDRRLSEQHRAILASDAVVFASAASVWEIAIKRSIGKLNAPDDLPTLLPRMQFQPLAVTLQH
ANAVGGLPHHHGDPFDRLLIAQAQVENLTILTSDPHFVRYNVALA

Nucleotide

• Length: 378 bp

>T37083 NZ_AP023243:4729887-4730264 [Mesorhizobium sp. 113-3-3]
ATGACGGTCGGCGCGTTTCTCGCCGACACCCATATCATCCTCTGGTCGATTTCGGACGACCGACGTCTCAGCGAGCAACA
CCGCGCTATCCTGGCTTCTGACGCGGTGGTGTTCGCGAGCGCGGCAAGTGTTTGGGAAATTGCCATCAAACGTTCGATCG
GGAAACTCAACGCGCCGGACGATCTGCCAACGCTGCTTCCAAGGATGCAATTTCAGCCGCTCGCCGTAACGCTCCAGCAT
GCGAACGCCGTCGGCGGCCTACCCCACCACCATGGTGATCCGTTCGACAGACTGCTGATTGCGCAGGCGCAGGTGGAGAA
CCTGACCATCCTGACATCCGACCCGCATTTCGTCCGCTACAATGTCGCTCTGGCCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8052.28 Da
• Isoelectric Point: 4.7954

>AT37083 WP_202354842.1 NZ_AP023243:4729666-4729890 [Mesorhizobium sp. 113-3-3]
MNVSIAEAKAKLSELVSRAEAGEEIILTRHGKVAARIVPPAAAEPLPRIGALKGKIWIADDFDELGPEWDEYVK

Nucleotide

• Length: 225 bp

>AT37083 NZ_AP023243:4729666-4729890 [Mesorhizobium sp. 113-3-3]
ATGAATGTTTCCATCGCCGAGGCCAAGGCTAAATTGTCTGAACTCGTCAGCCGCGCTGAAGCCGGCGAGGAGATCATACT
TACACGCCACGGCAAAGTGGCCGCGCGCATTGTACCGCCGGCGGCCGCCGAACCGCTGCCGCGTATCGGCGCCTTGAAGG
GCAAGATCTGGATTGCGGACGATTTTGATGAACTCGGTCCTGAGTGGGACGAGTACGTGAAATGA