Detailed information of TA system TA037082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 4455391..4455802
• Replicon: chromosome
• Accession: NZ_AP023243
• Organism: Mesorhizobium sp. 113-3-3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JG746_RS21790
• Protein ID: WP_202354616.1
• Coordinates: 4455391..4455591 (+)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JG746_RS21795
• Protein ID: WP_202354617.1
• Coordinates: 4455596..4455802 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG746_RS21780	4450617..4450928	+	312	WP_202354614.1	PilZ domain-containing protein	-
JG746_RS21785	4451601..4455383	+	3783	WP_202354615.1	vitamin B12-dependent ribonucleotide reductase	-
JG746_RS21790	4455391..4455591	+	201	WP_202354616.1	type II toxin-antitoxin system HicA family toxin	Toxin
JG746_RS21795	4455596..4455802	+	207	WP_202354617.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JG746_RS21800	4455832..4456458	-	627	WP_202354618.1	hypothetical protein	-
JG746_RS21805	4456451..4456972	-	522	WP_202354619.1	hypothetical protein	-
JG746_RS21810	4457016..4457987	-	972	WP_202354620.1	DUF3592 domain-containing protein	-
JG746_RS21815	4458131..4458739	-	609	WP_202354621.1	class I SAM-dependent methyltransferase	-
JG746_RS21820	4458779..4458940	-	162	WP_202354622.1	hypothetical protein	-
JG746_RS21825	4459046..4459957	+	912	WP_202354623.1	LysR family transcriptional regulator	-
JG746_RS21830	4459990..4460373	+	384	WP_202354624.1	VOC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-66)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7340.56 Da
• Isoelectric Point: 10.7459

>T37082 WP_202354616.1 NZ_AP023243:4455391-4455591 [Mesorhizobium sp. 113-3-3]
MPPRLTVREVIRLLETDGWYLVATKGSHRQYKHKIKAGRVTVAGKPSEEVAPGTLNSILKQSGLKE

Nucleotide

• Length: 201 bp

>T37082 NZ_AP023243:4455391-4455591 [Mesorhizobium sp. 113-3-3]
ATGCCACCTCGGCTTACAGTTCGCGAGGTTATTCGCTTGCTGGAGACTGACGGCTGGTATCTGGTTGCAACCAAGGGCAG
CCATCGCCAATATAAGCACAAAATCAAAGCCGGCCGCGTCACTGTGGCCGGCAAGCCGTCTGAAGAGGTTGCGCCAGGCA
CACTGAACAGCATCCTCAAACAGTCCGGTTTGAAGGAGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7305.26 Da
• Isoelectric Point: 4.0543

>AT37082 WP_202354617.1 NZ_AP023243:4455596-4455802 [Mesorhizobium sp. 113-3-3]
MRYAVVIEKAGDNFSAYVPDLPGCIATGATVPEVEIEIRDAIRFHIEGLRADGLDVPNGVSLAEYVEA

Nucleotide

• Length: 207 bp

>AT37082 NZ_AP023243:4455596-4455802 [Mesorhizobium sp. 113-3-3]
ATGCGCTACGCCGTAGTGATTGAAAAAGCAGGAGATAATTTCTCCGCTTATGTGCCGGACCTCCCGGGCTGCATCGCGAC
TGGTGCGACCGTGCCAGAAGTGGAAATCGAAATTCGCGACGCAATACGCTTCCACATTGAGGGCCTGCGTGCGGATGGCC
TGGACGTGCCAAACGGTGTCAGTCTCGCGGAGTACGTAGAGGCATAG