Detailed information of TA system TA037081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-VagC
• Location: 3232403..3233076
• Replicon: chromosome
• Accession: NZ_AP023243
• Organism: Mesorhizobium sp. 113-3-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JG746_RS15820
• Protein ID: WP_202358973.1
• Coordinates: 3232678..3233076 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JG746_RS15815
• Protein ID: WP_202358972.1
• Coordinates: 3232403..3232678 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG746_RS15790	3227881..3228861	+	981	WP_202358969.1	ABC transporter permease	-
JG746_RS15795	3228876..3229862	+	987	WP_202359381.1	ABC transporter permease	-
JG746_RS15800	3229865..3230413	+	549	WP_202358970.1	gluconokinase	-
JG746_RS15805	3230496..3230945	-	450	WP_010910348.1	Rrf2 family transcriptional regulator	-
JG746_RS15810	3231194..3232180	-	987	WP_202358971.1	sulfate ABC transporter substrate-binding protein	-
JG746_RS15815	3232403..3232678	+	276	WP_202358972.1	antitoxin	Antitoxin
JG746_RS15820	3232678..3233076	+	399	WP_202358973.1	type II toxin-antitoxin system VapC family toxin	Toxin
JG746_RS15825	3233091..3234131	-	1041	WP_010910344.1	sulfate/molybdate ABC transporter ATP-binding protein	-
JG746_RS15830	3234145..3235029	-	885	WP_202358974.1	sulfate ABC transporter permease subunit CysW	-
JG746_RS15835	3235022..3235873	-	852	WP_202358975.1	sulfate ABC transporter permease subunit CysT	-
JG746_RS15840	3235957..3236985	-	1029	WP_202358976.1	sulfate ABC transporter substrate-binding protein	-
JG746_RS15845	3237194..3237904	-	711	WP_202358977.1	M15 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-113)

Antitoxin

• SpoVT-AbrB domain (18-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14233.66 Da
• Isoelectric Point: 5.7489

>T37081 WP_202358973.1 NZ_AP023243:3232678-3233076 [Mesorhizobium sp. 113-3-3]
MRFMLDTNIISDMIRNPAGKAASAMVREGDAAVCTSIVVASELRYGCARKGSAKLLKKVEDLLAEIPVLPLDVPVDAEYG
ALRTELEAVGQPIGHNDLFIAAHACVLGAILVTASIGEFTRIRKLKVENWLE

Nucleotide

• Length: 399 bp

>T37081 NZ_AP023243:3232678-3233076 [Mesorhizobium sp. 113-3-3]
ATGCGGTTCATGCTGGATACGAACATCATCAGCGACATGATCCGGAACCCGGCTGGCAAGGCTGCCAGTGCAATGGTGCG
CGAGGGAGACGCCGCTGTGTGTACCAGCATCGTCGTCGCCTCTGAATTGCGGTATGGCTGCGCCAGGAAAGGCTCGGCCA
AGCTGCTCAAGAAGGTCGAGGACCTGCTGGCTGAAATCCCTGTCTTGCCGCTCGATGTGCCGGTGGACGCCGAGTACGGC
GCGCTTCGCACCGAGCTGGAGGCCGTTGGCCAACCCATTGGCCACAATGACCTTTTTATTGCCGCTCACGCCTGCGTGTT
AGGCGCCATTTTGGTGACGGCCAGCATCGGGGAGTTCACCCGGATACGGAAGCTGAAGGTCGAGAACTGGCTGGAATAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10144.59 Da
• Isoelectric Point: 4.8782

>AT37081 WP_202358972.1 NZ_AP023243:3232403-3232678 [Mesorhizobium sp. 113-3-3]
MPQHRHTATPPPKEAKLFRNNRSQAVRIPVEFELPGDKVLISREGGRLIIEPVRKPGLAALLAQWAKEAPLGPEDDFPEI
DDAPVEAEDIF

Nucleotide

• Length: 276 bp

>AT37081 NZ_AP023243:3232403-3232678 [Mesorhizobium sp. 113-3-3]
ATGCCCCAGCATCGCCACACAGCAACGCCGCCACCGAAGGAGGCGAAACTGTTCCGCAACAACCGCAGCCAGGCGGTGCG
CATTCCTGTCGAATTCGAGCTCCCTGGCGACAAGGTTCTGATCAGCCGTGAAGGCGGCCGCCTGATCATTGAGCCGGTCC
GCAAACCCGGCCTTGCCGCGCTGCTCGCCCAATGGGCGAAAGAGGCGCCGCTTGGTCCTGAGGACGACTTTCCCGAGATC
GACGATGCGCCTGTCGAAGCCGAGGACATTTTTTGA