Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3091096..3092726 Replicon chromosome
Accession NZ_AP023243
Organism Mesorhizobium sp. 113-3-3

Toxin (Protein)


Gene name HipA2 Uniprot ID -
Locus tag JG746_RS15040 Protein ID WP_202358837.1
Coordinates 3091374..3092726 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag JG746_RS15035 Protein ID WP_202359374.1
Coordinates 3091096..3091374 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG746_RS15010 3087076..3087357 - 282 WP_202358832.1 hypothetical protein -
JG746_RS15015 3087669..3088097 + 429 WP_202358833.1 VOC family protein -
JG746_RS15020 3088313..3088828 + 516 WP_202358834.1 hypothetical protein -
JG746_RS15025 3088973..3089590 + 618 WP_202358835.1 hypothetical protein -
JG746_RS15030 3089606..3090676 + 1071 WP_202358836.1 D-alanine--D-alanine ligase -
JG746_RS15035 3091096..3091374 + 279 WP_202359374.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
JG746_RS15040 3091374..3092726 + 1353 WP_202358837.1 HipA domain-containing protein Toxin
JG746_RS15045 3092920..3094902 + 1983 WP_202358838.1 AI-2E family transporter -
JG746_RS15050 3095054..3095407 - 354 WP_202359375.1 hypothetical protein -
JG746_RS15055 3095493..3095843 + 351 WP_202358839.1 hypothetical protein -
JG746_RS15060 3095962..3097446 - 1485 WP_202358840.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(156-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-87)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 48298.92 Da        Isoelectric Point: 5.2131

>T37080 WP_202358837.1 NZ_AP023243:3091374-3092726 [Mesorhizobium sp. 113-3-3]
MDALALDVRLDGFAEPIGVLARDGNGAVAYAYRPDYVANPDAVALSLSLPLTDEPYGDVATRPFFDNLLQERDTALADIM
AREGLARDDIAGLLFYLGKDCAGALSVLPAGAPPVKVPGDYDRDYIPLGTERMERIVDALHRRRRLPDGTADPSPLAGVQ
SKIALTVLPDGSFGEPRPGSGAPTTHILKVPDPGHLHDARDEAEALSLSRALGFETTDAVVVPFDAAAALLITRFDRALT
RDGRIVRIHQEDFAQALGLPAALKYERRGVPGRRFDAQAIRHVLEATADPLDSKEIFVRATLFDLMIGNADGHAKNFALL
HEAGGRIRMAPRYDLLPTRLDASLTDELAFRIGSADRLEAISADDFSAFLQALGIDSAAARKRMRAGYTADIAGSLAQQL
AGLDKRNMKRFADLIASNIATLTAAFGLGVPAAVERRDAFLGRAGGWLMS

Download         Length: 1353 bp

>T37080 NZ_AP023243:3091374-3092726 [Mesorhizobium sp. 113-3-3]
ATGGACGCCCTGGCGCTCGATGTCCGGCTCGACGGCTTCGCCGAGCCGATCGGCGTCCTGGCGCGTGACGGCAATGGCGC
GGTTGCCTATGCGTATCGGCCCGACTACGTCGCCAATCCCGATGCCGTTGCCTTGTCCCTGTCCCTGCCATTGACCGACG
AACCCTATGGCGACGTTGCCACCCGGCCGTTCTTCGACAATCTGCTGCAGGAGCGCGACACAGCACTTGCCGACATCATG
GCCCGCGAGGGCCTCGCCCGCGACGACATTGCCGGCCTGTTGTTTTATCTCGGCAAGGACTGCGCCGGCGCCCTGTCGGT
GCTGCCTGCGGGGGCGCCTCCCGTCAAGGTCCCCGGAGACTACGACCGTGACTACATACCGCTCGGCACGGAGCGGATGG
AGCGGATCGTGGACGCGCTGCATCGGCGCCGTCGTCTGCCGGATGGCACTGCCGACCCGTCGCCCCTGGCCGGCGTTCAA
AGCAAGATCGCGCTGACCGTGCTGCCCGACGGCTCTTTCGGCGAGCCGCGGCCAGGTTCGGGCGCGCCGACCACCCACAT
ATTGAAGGTTCCCGATCCGGGCCATCTCCACGATGCGCGCGACGAGGCCGAGGCGCTCTCGCTGTCGCGAGCGCTAGGCT
TCGAGACGACCGACGCCGTGGTCGTGCCTTTCGACGCGGCCGCGGCTCTCCTGATCACCCGCTTCGACCGCGCGCTTACC
CGTGACGGGCGGATCGTGCGTATCCATCAGGAGGACTTCGCACAGGCGCTCGGCTTGCCGGCGGCGCTGAAATATGAACG
GCGTGGAGTGCCCGGCCGGCGTTTTGACGCGCAGGCCATCCGCCATGTGCTCGAGGCGACAGCGGACCCATTGGACTCCA
AGGAGATCTTTGTCAGGGCCACCCTGTTCGACCTGATGATCGGCAACGCCGATGGCCATGCCAAGAATTTCGCGCTGCTT
CACGAGGCCGGCGGGCGCATTCGCATGGCGCCACGCTACGACCTTCTGCCGACGCGCCTCGACGCCAGCCTGACCGATGA
GCTTGCCTTCAGGATCGGGTCGGCGGATCGGCTGGAGGCAATTTCCGCCGACGACTTTTCAGCCTTCCTGCAGGCGCTCG
GCATCGATAGCGCCGCCGCGCGCAAGCGTATGCGGGCGGGCTACACGGCCGATATAGCAGGGTCGTTGGCGCAGCAATTG
GCCGGCCTCGACAAGCGAAACATGAAGCGCTTCGCCGATCTCATCGCATCGAACATCGCAACACTGACAGCGGCATTCGG
GCTTGGCGTGCCGGCGGCGGTCGAGCGGCGCGACGCGTTTCTCGGCCGGGCCGGGGGGTGGCTGATGAGTTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9940.40 Da        Isoelectric Point: 10.1732

>AT37080 WP_202359374.1 NZ_AP023243:3091096-3091374 [Mesorhizobium sp. 113-3-3]
MLEADVREQATTQISAKGAEAEPSIIASPADLGRLVRKVRESRRLSQQEFADLAGVGRRFLSELENGKPTLELGKVLKVA
NAAGIALLARER

Download         Length: 279 bp

>AT37080 NZ_AP023243:3091096-3091374 [Mesorhizobium sp. 113-3-3]
ATGCTCGAAGCGGATGTGAGGGAGCAGGCAACGACGCAAATCAGCGCCAAAGGGGCCGAGGCCGAGCCCTCCATCATCGC
ATCCCCGGCCGATCTCGGCCGGCTGGTGCGCAAGGTGCGCGAGAGCCGGCGGCTTTCGCAGCAGGAATTCGCCGATCTCG
CCGGCGTCGGACGGCGTTTCCTGTCGGAATTGGAGAACGGCAAGCCGACGCTGGAGCTGGGCAAGGTGCTGAAGGTCGCC
AATGCCGCCGGCATCGCGCTTCTCGCCAGGGAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References