Detailed information of TA system TA037079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2822648..2823243
• Replicon: chromosome
• Accession: NZ_AP023243
• Organism: Mesorhizobium sp. 113-3-3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JG746_RS13735
• Protein ID: WP_202358610.1
• Coordinates: 2823055..2823243 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JG746_RS13730
• Protein ID: WP_202358609.1
• Coordinates: 2822648..2823049 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG746_RS13705	2818792..2819418	-	627	WP_202358604.1	class I SAM-dependent methyltransferase	-
JG746_RS13710	2819634..2820080	+	447	WP_202358605.1	SRPBCC domain-containing protein	-
JG746_RS13715	2820109..2820942	-	834	WP_202358606.1	helix-turn-helix transcriptional regulator	-
JG746_RS13720	2821018..2821902	+	885	WP_202358607.1	SDR family oxidoreductase	-
JG746_RS13725	2821915..2822613	-	699	WP_202358608.1	RibD family protein	-
JG746_RS13730	2822648..2823049	-	402	WP_202358609.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JG746_RS13735	2823055..2823243	-	189	WP_202358610.1	type II toxin-antitoxin system HicA family toxin	Toxin
JG746_RS13740	2823605..2824552	+	948	WP_202358611.1	substrate-binding domain-containing protein	-
JG746_RS13745	2824801..2826399	+	1599	WP_202358612.1	sugar ABC transporter ATP-binding protein	-
JG746_RS13750	2826396..2827412	+	1017	WP_202358613.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7049.14 Da
• Isoelectric Point: 11.3260

>T37079 WP_202358610.1 NZ_AP023243:c2823243-2823055 [Mesorhizobium sp. 113-3-3]
MNSAEIIRLLQADGWFEVAQKGSHAQFKHRDKQGRVTVAHPKRDIPIGTLRSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T37079 NZ_AP023243:c2823243-2823055 [Mesorhizobium sp. 113-3-3]
ATGAATAGCGCAGAGATTATCCGCTTGTTGCAAGCTGATGGTTGGTTTGAGGTTGCCCAAAAGGGCAGCCATGCGCAATT
CAAACACCGTGACAAGCAAGGGCGGGTCACCGTTGCCCATCCCAAGCGCGACATCCCGATAGGCACCCTTCGCAGCATCG
AAAAGCAATCCGGACTGAAACTGAGGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14212.97 Da
• Isoelectric Point: 4.3303

>AT37079 WP_202358609.1 NZ_AP023243:c2823049-2822648 [Mesorhizobium sp. 113-3-3]
MKQYIGLIHKDADSDFGVSFPDFPGVITAGKDLDDARSMAEQALALHIEGLAEDGEAIPEPSSLEAVMADADNRDGVAIL
VAARTEARKAVRINVTLPDDVLRRIDAFAEAHGYTRSGFLAKAAEKAMELESA

Nucleotide

• Length: 402 bp

>AT37079 NZ_AP023243:c2823049-2822648 [Mesorhizobium sp. 113-3-3]
ATGAAGCAGTATATCGGACTTATCCATAAGGATGCCGACAGCGACTTCGGTGTGTCTTTCCCTGATTTCCCTGGCGTGAT
CACCGCCGGAAAGGATCTCGATGACGCCCGGTCCATGGCTGAACAAGCGCTCGCCCTCCACATCGAAGGGCTGGCCGAGG
ATGGCGAGGCCATTCCGGAGCCTTCCAGTCTGGAGGCCGTGATGGCGGATGCCGATAATCGTGACGGTGTTGCGATCCTG
GTCGCGGCCAGGACCGAGGCCAGGAAGGCGGTGCGCATCAACGTGACGCTGCCGGACGACGTTCTGCGACGGATTGATGC
CTTTGCCGAAGCCCATGGCTATACTCGATCCGGGTTTCTCGCGAAGGCGGCTGAGAAAGCGATGGAGCTTGAATCGGCCT
GA