37078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 531561..532246 Replicon chromosome
Accession NZ_AP023243
Organism Mesorhizobium sp. 113-3-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JG746_RS02420 Protein ID WP_202356729.1
Coordinates 531824..532246 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JG746_RS02415 Protein ID WP_202356728.1
Coordinates 531561..531827 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG746_RS02390 526617..527558 + 942 WP_202356724.1 sugar ABC transporter substrate-binding protein -
JG746_RS02395 527668..528744 + 1077 WP_202356725.1 ABC transporter permease -
JG746_RS02400 528747..529514 + 768 WP_010912863.1 sugar ABC transporter ATP-binding protein -
JG746_RS02405 529635..530630 + 996 WP_202356726.1 inositol 2-dehydrogenase -
JG746_RS02410 530668..531462 + 795 WP_202356727.1 SDR family oxidoreductase -
JG746_RS02415 531561..531827 + 267 WP_202356728.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JG746_RS02420 531824..532246 + 423 WP_202356729.1 type II toxin-antitoxin system VapC family toxin Toxin
JG746_RS02425 532787..533878 + 1092 WP_202356730.1 3-deoxy-7-phosphoheptulonate synthase -
JG746_RS02430 533927..534562 - 636 WP_202356731.1 LysE family translocator -
JG746_RS02435 534692..535387 + 696 WP_202356732.1 YafY family transcriptional regulator -
JG746_RS02440 535400..536509 - 1110 WP_202356733.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15546.73 Da        Isoelectric Point: 4.4480

>T37078 WP_202356729.1 NZ_AP023243:531824-532246 [Mesorhizobium sp. 113-3-3]
VRLLLDTNVLSEVTRPAPDARVLDWLEGLDEDRSFISVVSIAEIRRGVALMDEGRKREALADWLARDLPQRFDQRVLPVD
EPVALAWGDLMGLAKRSGRGLSSMDGLIAATAIAQQLTLATRNTRDFEGFGIELFDPWTA

Download         Length: 423 bp

>T37078 NZ_AP023243:531824-532246 [Mesorhizobium sp. 113-3-3]
GTGAGACTACTGCTCGATACCAATGTCCTGTCCGAGGTGACAAGGCCTGCGCCGGACGCACGCGTTCTGGACTGGCTGGA
GGGACTTGACGAGGACCGCTCATTCATCAGTGTCGTGTCGATCGCCGAAATCCGGCGCGGCGTCGCGCTCATGGACGAAG
GTCGGAAGCGCGAGGCACTCGCCGACTGGCTCGCTCGGGACCTGCCACAGCGCTTCGATCAGAGGGTTTTGCCGGTGGAC
GAACCGGTTGCCTTGGCCTGGGGCGATCTGATGGGCCTTGCGAAGCGCAGCGGTCGCGGCCTGTCGTCGATGGACGGGCT
GATCGCGGCCACGGCGATCGCGCAGCAGCTCACCTTGGCAACACGCAATACCAGGGATTTCGAAGGCTTTGGGATAGAAC
TCTTCGATCCCTGGACGGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9817.24 Da        Isoelectric Point: 8.7460

>AT37078 WP_202356728.1 NZ_AP023243:531561-531827 [Mesorhizobium sp. 113-3-3]
MMAAPKVDTDWTVAGAKARLSEVIERAQSSPQTITKNGKPSVVVVSAEEWQRKTMRKGTLAQFLLESPLRGADLDLERQR
DEPRDLPL

Download         Length: 267 bp

>AT37078 NZ_AP023243:531561-531827 [Mesorhizobium sp. 113-3-3]
ATGATGGCCGCACCTAAAGTGGATACCGATTGGACGGTTGCTGGGGCAAAGGCACGGCTCTCGGAAGTTATCGAGCGCGC
ACAGTCTTCGCCGCAGACAATCACTAAAAACGGCAAACCAAGCGTGGTTGTGGTCTCGGCCGAGGAATGGCAGCGAAAGA
CCATGCGCAAGGGTACGCTTGCGCAGTTCCTGCTGGAGTCGCCGCTGCGCGGCGCCGACCTCGACCTGGAGCGTCAGCGC
GACGAACCGCGTGACTTGCCCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References