Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 3715860..3716533 Replicon chromosome
Accession NZ_AP023242
Organism Mesorhizobium sp. 113-1-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN279_RS18035 Protein ID WP_096447608.1
Coordinates 3716135..3716533 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN279_RS18030 Protein ID WP_202353531.1
Coordinates 3715860..3716135 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN279_RS18005 3711197..3712183 + 987 WP_202353757.1 ABC transporter permease -
JN279_RS18010 3712186..3712734 + 549 WP_202353528.1 gluconokinase -
JN279_RS18015 3712729..3713859 - 1131 WP_202353529.1 hypothetical protein -
JN279_RS18020 3713942..3714391 - 450 WP_095202067.1 Rrf2 family transcriptional regulator -
JN279_RS18025 3714641..3715627 - 987 WP_202353530.1 sulfate ABC transporter substrate-binding protein -
JN279_RS18030 3715860..3716135 + 276 WP_202353531.1 antitoxin Antitoxin
JN279_RS18035 3716135..3716533 + 399 WP_096447608.1 type II toxin-antitoxin system VapC family toxin Toxin
JN279_RS18040 3716548..3717588 - 1041 WP_096447606.1 sulfate/molybdate ABC transporter ATP-binding protein -
JN279_RS18045 3717658..3718542 - 885 WP_096447604.1 sulfate ABC transporter permease subunit CysW -
JN279_RS18050 3718535..3719386 - 852 WP_096447602.1 sulfate ABC transporter permease subunit CysT -
JN279_RS18055 3719468..3720496 - 1029 WP_095202074.1 sulfate ABC transporter substrate-binding protein -
JN279_RS18060 3720706..3721458 - 753 WP_096457502.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin

SpoVT-AbrB domain

(18-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14260.68 Da        Isoelectric Point: 5.7489

>T37076 WP_096447608.1 NZ_AP023242:3716135-3716533 [Mesorhizobium sp. 113-1-2]
MRFMLDTNIISDMIRNPAGKAASAMVREGDAAVCTSIVVASELRYGCARKGSAKLLKKVEDLLAEIPVLPLDVPVDAEYG
ALRTELEAVGQPIGHNDLFIAAHACVLGAILVTANIGEFTRIRKLKVENWLE

Download         Length: 399 bp

>T37076 NZ_AP023242:3716135-3716533 [Mesorhizobium sp. 113-1-2]
ATGCGGTTCATGCTGGATACGAACATCATCAGCGACATGATCCGGAACCCGGCCGGCAAGGCTGCCAGTGCAATGGTGCG
CGAGGGAGACGCCGCTGTGTGTACCAGCATCGTCGTCGCCTCTGAATTGCGGTATGGCTGCGCCAGGAAAGGCTCGGCCA
AGCTGCTCAAGAAGGTCGAGGACCTGCTGGCTGAAATCCCTGTCTTGCCGCTCGATGTGCCGGTGGACGCCGAGTACGGC
GCGCTTCGCACCGAGCTGGAAGCCGTTGGCCAACCCATTGGCCACAATGACCTTTTTATTGCCGCTCACGCCTGCGTGTT
AGGCGCCATTTTGGTGACGGCCAACATCGGGGAGTTCACCCGGATACGGAAGCTGAAGGTCGAGAACTGGCTGGAATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10232.65 Da        Isoelectric Point: 4.7010

>AT37076 WP_202353531.1 NZ_AP023242:3715860-3716135 [Mesorhizobium sp. 113-1-2]
MPQHRHTTTPPPKEAKLFRNNRSQAVRIPVEFELPGDKVLISREGDRLIIEPVRKPGLAALLAQWAKEAPLGPEDDFPEI
DDAPVEAEDIF

Download         Length: 276 bp

>AT37076 NZ_AP023242:3715860-3716135 [Mesorhizobium sp. 113-1-2]
ATGCCCCAGCATCGCCACACAACAACGCCGCCACCGAAGGAGGCGAAACTCTTCCGCAACAACCGCAGCCAGGCGGTGCG
CATTCCTGTCGAATTCGAACTCCCTGGCGACAAGGTTCTGATCAGCCGTGAAGGCGACCGCCTGATCATTGAGCCGGTCC
GAAAACCCGGCCTTGCCGCGCTGCTCGCCCAATGGGCAAAAGAGGCGCCGCTTGGTCCTGAGGACGACTTTCCCGAGATC
GACGATGCGCCTGTCGAAGCCGAGGACATTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References