Detailed information of TA system TA037062

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2919817..2920661
• Replicon: chromosome
• Accession: NZ_AP023237
• Organism: Escherichia coli strain F070

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: FJI53_RS14145
• Protein ID: WP_000854686.1
• Coordinates: 2919817..2920200 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: FJI53_RS14150
• Protein ID: WP_001285602.1
• Coordinates: 2920281..2920661 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FJI53_RS14105	2914820..2915311	-	492	WP_001297187.1	DUF1097 domain-containing protein	-
FJI53_RS14110	2915413..2915967	-	555	WP_001001902.1	molecular chaperone YcdY	-
FJI53_RS14115	2915991..2916728	-	738	WP_000283664.1	zinc-binding phosphatase	-
FJI53_RS14120	2916783..2917721	-	939	WP_000351311.1	glyoxylate/hydroxypyruvate reductase GhrA	-
FJI53_RS14130	2918192..2919033	-	842	Protein_2768	DUF4942 domain-containing protein	-
FJI53_RS14135	2919118..2919315	-	198	WP_000839253.1	DUF957 domain-containing protein	-
FJI53_RS14140	2919332..2919820	-	489	WP_032180032.1	hypothetical protein	-
FJI53_RS14145	2919817..2920200	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
FJI53_RS14150	2920281..2920661	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FJI53_RS14155	2920672..2921355	-	684	WP_000086768.1	hypothetical protein	-
FJI53_RS14160	2921374..2921595	-	222	WP_000692298.1	DUF987 domain-containing protein	-
FJI53_RS14165	2921658..2922134	-	477	WP_001186726.1	RadC family protein	-
FJI53_RS14170	2922150..2922635	-	486	WP_000214307.1	antirestriction protein	-
FJI53_RS14175	2922727..2923548	-	822	WP_001761104.1	DUF945 domain-containing protein	-
FJI53_RS14180	2923649..2923857	-	209	Protein_2778	DUF905 family protein	-
FJI53_RS14185	2923958..2924413	-	456	WP_000581506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T37062 WP_000854686.1 NZ_AP023237:c2920200-2919817 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T37062 NZ_AP023237:c2920200-2919817 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT37062 WP_001285602.1 NZ_AP023237:c2920661-2920281 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT37062 NZ_AP023237:c2920661-2920281 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG