Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2675047..2675685 Replicon chromosome
Accession NZ_AP023235
Organism Escherichia coli strain YJ6

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HXS64_RS12930 Protein ID WP_000813794.1
Coordinates 2675509..2675685 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HXS64_RS12925 Protein ID WP_001270286.1
Coordinates 2675047..2675463 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS64_RS12905 2670199..2671140 - 942 WP_001251313.1 ABC transporter permease -
HXS64_RS12910 2671141..2672154 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
HXS64_RS12915 2672172..2673317 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HXS64_RS12920 2673562..2674968 - 1407 WP_047603724.1 PLP-dependent aminotransferase family protein -
HXS64_RS12925 2675047..2675463 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HXS64_RS12930 2675509..2675685 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HXS64_RS12935 2675907..2676137 + 231 WP_000494244.1 YncJ family protein -
HXS64_RS12940 2676229..2678190 - 1962 WP_047603723.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HXS64_RS12945 2678263..2678799 - 537 WP_000429133.1 DNA-binding transcriptional regulator SutR -
HXS64_RS12950 2678852..2680066 + 1215 WP_071597387.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T37033 WP_000813794.1 NZ_AP023235:c2675685-2675509 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T37033 NZ_AP023235:c2675685-2675509 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT37033 WP_001270286.1 NZ_AP023235:c2675463-2675047 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT37033 NZ_AP023235:c2675463-2675047 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References