Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1166590..1167250 Replicon chromosome
Accession NZ_AP023235
Organism Escherichia coli strain YJ6

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag HXS64_RS05585 Protein ID WP_029701967.1
Coordinates 1166837..1167250 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HXS64_RS05580 Protein ID WP_000354046.1
Coordinates 1166590..1166856 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS64_RS05555 1161878..1162621 + 744 WP_047603407.1 SDR family oxidoreductase -
HXS64_RS05560 1162678..1164111 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
HXS64_RS05565 1164156..1164467 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
HXS64_RS05570 1164631..1165290 + 660 WP_047603410.1 hemolysin III family protein -
HXS64_RS05575 1165367..1166347 - 981 WP_000886083.1 tRNA-modifying protein YgfZ -
HXS64_RS05580 1166590..1166856 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HXS64_RS05585 1166837..1167250 + 414 WP_029701967.1 protein YgfX Toxin
HXS64_RS05590 1167284..1167805 - 522 WP_001055874.1 flavodoxin FldB -
HXS64_RS05595 1167917..1168813 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HXS64_RS05600 1168837..1169547 + 711 WP_000715231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HXS64_RS05605 1169553..1171286 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T37022 WP_029701967.1 NZ_AP023235:1166837-1167250 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T37022 NZ_AP023235:1166837-1167250 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGCTTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATCAAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT37022 WP_000354046.1 NZ_AP023235:1166590-1166856 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37022 NZ_AP023235:1166590-1166856 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCAGACC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAATTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References