Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4040881..4041712 Replicon chromosome
Accession NZ_AP023230
Organism Escherichia coli strain YJ4

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HXS62_RS19280 Protein ID WP_000854814.1
Coordinates 4040881..4041255 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag HXS62_RS19285 Protein ID WP_001285585.1
Coordinates 4041344..4041712 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS62_RS19240 4036285..4037506 + 1222 Protein_3734 ISL3-like element ISKox3 family transposase -
HXS62_RS19245 4037563..4038036 + 474 WP_032224276.1 DNA gyrase inhibitor SbmC -
HXS62_RS19250 4038233..4039291 + 1059 WP_001200891.1 FUSC family protein -
HXS62_RS19255 4039463..4039792 + 330 WP_000450409.1 DUF496 family protein -
HXS62_RS19260 4039893..4040075 - 183 WP_001016348.1 hypothetical protein -
HXS62_RS19265 4040147..4040275 + 129 Protein_3739 transposase domain-containing protein -
HXS62_RS19270 4040564..4040677 - 114 WP_001161660.1 DUF957 domain-containing protein -
HXS62_RS19275 4040690..4040884 - 195 WP_000988600.1 hypothetical protein -
HXS62_RS19280 4040881..4041255 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HXS62_RS19285 4041344..4041712 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HXS62_RS19290 4041786..4042007 - 222 WP_000692323.1 DUF987 domain-containing protein -
HXS62_RS19295 4042070..4042546 - 477 WP_001186726.1 RadC family protein -
HXS62_RS19300 4042562..4043041 - 480 WP_000860087.1 antirestriction protein -
HXS62_RS19305 4043123..4043941 - 819 WP_001234629.1 DUF945 domain-containing protein -
HXS62_RS19310 4044041..4044274 - 234 WP_001119729.1 DUF905 family protein -
HXS62_RS19315 4044382..4044807 - 426 WP_001538006.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T37000 WP_000854814.1 NZ_AP023230:c4041255-4040881 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T37000 NZ_AP023230:c4041255-4040881 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT37000 WP_001285585.1 NZ_AP023230:c4041712-4041344 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT37000 NZ_AP023230:c4041712-4041344 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References