Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2980347..2981182 Replicon chromosome
Accession NZ_AP023230
Organism Escherichia coli strain YJ4

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1C0Y405
Locus tag HXS62_RS14270 Protein ID WP_001774607.1
Coordinates 2980347..2980724 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag HXS62_RS14275 Protein ID WP_001774606.1
Coordinates 2980814..2981182 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS62_RS14240 2975754..2976731 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
HXS62_RS14245 2976728..2977906 + 1179 WP_000094991.1 type II secretion system protein GspL -
HXS62_RS14250 2977908..2978444 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
HXS62_RS14255 2978726..2979568 - 843 WP_032152755.1 DUF4942 domain-containing protein -
HXS62_RS14260 2979653..2979850 - 198 WP_032152719.1 DUF957 domain-containing protein -
HXS62_RS14265 2979862..2980350 - 489 WP_001774608.1 hypothetical protein -
HXS62_RS14270 2980347..2980724 - 378 WP_001774607.1 TA system toxin CbtA family protein Toxin
HXS62_RS14275 2980814..2981182 - 369 WP_001774606.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HXS62_RS14280 2981232..2981876 - 645 WP_001774605.1 hypothetical protein -
HXS62_RS14285 2981895..2982116 - 222 WP_000692312.1 DUF987 domain-containing protein -
HXS62_RS14290 2982179..2982655 - 477 WP_001297237.1 RadC family protein -
HXS62_RS14295 2982671..2983150 - 480 WP_032152717.1 antirestriction protein -
HXS62_RS14300 2983489..2984307 - 819 WP_016238867.1 DUF945 domain-containing protein -
HXS62_RS14305 2984406..2984639 - 234 WP_126675705.1 DUF905 family protein -
HXS62_RS14310 2984645..2985322 - 678 WP_001097305.1 hypothetical protein -
HXS62_RS14315 2985470..2986150 - 681 WP_032082725.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2978593..3022045 43452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14218.20 Da        Isoelectric Point: 7.8045

>T36997 WP_001774607.1 NZ_AP023230:c2980724-2980347 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T36997 NZ_AP023230:c2980724-2980347 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT36997 WP_001774606.1 NZ_AP023230:c2981182-2980814 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT36997 NZ_AP023230:c2981182-2980814 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y405

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References