Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 857226..858058 Replicon chromosome
Accession NZ_AP023226
Organism Escherichia coli strain YJ3

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag HXS63_RS04120 Protein ID WP_000854753.1
Coordinates 857226..857600 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NQ68
Locus tag HXS63_RS04125 Protein ID WP_001540478.1
Coordinates 857690..858058 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS63_RS04085 852293..852892 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
HXS63_RS04090 852895..853872 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
HXS63_RS04095 853869..855047 + 1179 WP_000094991.1 type II secretion system protein GspL -
HXS63_RS04100 855049..855585 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
HXS63_RS04105 855866..856435 - 570 WP_001560692.1 DUF4942 domain-containing protein -
HXS63_RS04110 856532..856729 - 198 WP_000839281.1 DUF957 domain-containing protein -
HXS63_RS04115 856741..857229 - 489 WP_000777545.1 hypothetical protein -
HXS63_RS04120 857226..857600 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
HXS63_RS04125 857690..858058 - 369 WP_001540478.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HXS63_RS04130 858221..858442 - 222 WP_000692311.1 DUF987 domain-containing protein -
HXS63_RS04135 858505..858981 - 477 WP_001186786.1 RadC family protein -
HXS63_RS04140 858997..859482 - 486 WP_000214398.1 antirestriction protein -
HXS63_RS04145 859573..860391 - 819 Protein_810 DUF945 domain-containing protein -
HXS63_RS04150 860481..860714 - 234 WP_001278283.1 DUF905 family protein -
HXS63_RS04155 860720..861397 - 678 WP_001097301.1 hypothetical protein -
HXS63_RS04160 861545..862225 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T36956 WP_000854753.1 NZ_AP023226:c857600-857226 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T36956 NZ_AP023226:c857600-857226 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.53 Da        Isoelectric Point: 7.8398

>AT36956 WP_001540478.1 NZ_AP023226:c858058-857690 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT36956 NZ_AP023226:c858058-857690 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB S1NQ68

References