Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4142192..4143027 Replicon chromosome
Accession NZ_AP023224
Organism Escherichia coli strain YJ1

Toxin (Protein)


Gene name yeeV Uniprot ID B1LDL9
Locus tag HXS59_RS19925 Protein ID WP_001094444.1
Coordinates 4142192..4142569 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag HXS59_RS19930 Protein ID WP_001285607.1
Coordinates 4142659..4143027 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS59_RS19895 4137405..4138511 + 1107 WP_001341302.1 N-acetylneuraminate epimerase -
HXS59_RS19900 4138576..4139556 + 981 WP_000991415.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
HXS59_RS19905 4139564..4140214 - 651 WP_001037966.1 HNH endonuclease -
HXS59_RS19910 4141259..4141405 - 147 WP_001290178.1 hypothetical protein -
HXS59_RS19915 4141490..4141687 - 198 WP_001327226.1 DUF957 domain-containing protein -
HXS59_RS19920 4141707..4142195 - 489 WP_000761685.1 hypothetical protein -
HXS59_RS19925 4142192..4142569 - 378 WP_001094444.1 TA system toxin CbtA family protein Toxin
HXS59_RS19930 4142659..4143027 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HXS59_RS19935 4143107..4143328 - 222 WP_000692350.1 DUF987 domain-containing protein -
HXS59_RS19940 4143415..4143891 - 477 WP_001384029.1 RadC family protein -
HXS59_RS19945 4143906..4144391 - 486 WP_000213722.1 antirestriction protein -
HXS59_RS19950 4144483..4145301 - 819 WP_085668755.1 DUF945 domain-containing protein -
HXS59_RS19955 4145391..4145600 - 210 WP_032150870.1 DUF905 family protein -
HXS59_RS19960 4145630..4146307 - 678 WP_001097301.1 hypothetical protein -
HXS59_RS19965 4146455..4147135 - 681 WP_001282919.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4134611..4185508 50897


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14087.02 Da        Isoelectric Point: 7.3523

>T36944 WP_001094444.1 NZ_AP023224:c4142569-4142192 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T36944 NZ_AP023224:c4142569-4142192 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT36944 WP_001285607.1 NZ_AP023224:c4143027-4142659 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT36944 NZ_AP023224:c4143027-4142659 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1LDL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References